Degradable poly(ethylene glycol) hydrogels with controlled...

Details Degradable poly(ethylene glycol) hydrogels with controlled... Degradable poly(ethylene glycol) hydrogels with controlled...

2011-06-21

2011-06-21

Richter, Johann R (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S078310, C424S078370, C528S494000, C528S496000

Reexamination Certificate

active

07964217

ABSTRACT:
This invention relates to hydrolytically degradable gels of crosslinked poly(ethylene) glycol (PEG) structures. Addition of water causes these crosslinked structures to swell and become hydrogels. The hydrogels can be prepared by reacting two different PEG derivatives containing functional moieties at the chain ends that react with each other to form new covalent linkages between polymer chains. The PEG derivatives are chosen to provide covalent linkages within the crosslinked structure that are hydrolytically degradable. Hydrolytic degradation can provide for dissolution of the gel components and for controlled release of trapped molecules, including drugs. Reagents other than PEG can be avoided. The hydrolysis rates can be controlled by varying atoms adjacent to the hydrolytically degradable functional groups to provide substantially precise control for drug delivery in vivo.

REFERENCES:
patent: 3419006 (1968-12-01), King
patent: 3963805 (1976-06-01), Chu
patent: 4179337 (1979-12-01), Davis et al.
patent: 4424311 (1984-01-01), Nagaoka et al.
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 4894238 (1990-01-01), Embry et al.
patent: 5192743 (1993-03-01), Hsu
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5550178 (1996-08-01), Desai et al.
patent: 5567422 (1996-10-01), Greenwald
patent: 5571844 (1996-11-01), Stüber
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5607687 (1997-03-01), Bezwada et al.
patent: 5610241 (1997-03-01), Lee et al.
patent: 5618528 (1997-04-01), Cooper et al.
patent: 5626863 (1997-05-01), Hubbell et al.
patent: 5648088 (1997-07-01), Bezwada et al.
patent: 5648506 (1997-07-01), Desai et al.
patent: 5698213 (1997-12-01), Jamiolkowski et al.
patent: 5730968 (1998-03-01), Butterfield et al.
patent: 5874500 (1999-02-01), Rhee et al.
patent: 6051648 (2000-04-01), Rhee et al.
patent: 6166130 (2000-12-01), Rhee et al.
patent: 6214966 (2001-04-01), Harris
patent: 6258351 (2001-07-01), Harris
patent: 6323278 (2001-11-01), Rhee et al.
patent: 6348558 (2002-02-01), Harris et al.
patent: 6362276 (2002-03-01), Harris et al.
patent: 6432397 (2002-08-01), Harris
patent: 6515100 (2003-02-01), Harris
patent: 6558658 (2003-05-01), Harris
patent: 2002/0013408 (2002-01-01), Rhee et al.
patent: 0 473 268 (1992-03-01), None
patent: 0 593 284 (1994-04-01), None
patent: 0 771 832 (1997-05-01), None
patent: 0 794 211 (1997-09-01), None
patent: 0 841 360 (1998-05-01), None
patent: WO 92/00748 (1992-01-01), None
patent: WO 93/24476 (1993-12-01), None
patent: WO 94/03155 (1994-02-01), None
patent: WO 95/35093 (1995-12-01), None
patent: WO 96/20012 (1996-07-01), None
patent: WO 97/22371 (1997-06-01), None
The Aldrich Catalog, http://www.sigmaaldrich.com/etc/medialib/docs/Aldrich/General—Information/glossary.Par.0001.File.tmp/glossary.pdf, obtained online on Jan. 11, 2009.
J.M. Harris, Ed., “Biomedical and Biotechnical Applications of Poly(Ethylene Glycol) Chemistry”, Plenum, New York, 1992.
Greenwald et al., “Highly Water Soluble Taxol Derivatives: 7-Polyethylene Glycol Carbamates and Carbonates”,J. Org. Chem., vol. 60, No. 2, pp. 331-336, 1995.
Sawhney et al., “Biorodible Hydrogels Based on Photopolymerized Poly(Ethylene Glycol)-co-pol(α-hydroxy acid), Diacrylate Macromers”,Macromolecules, vol. 26, No. 4, pp. 581-587 (1993).
Gayet et al., “High Water Content BSA-PEG Hydrogel for Controlled Release Device: Evaluation of the Drug Release Properties”,Journal of Controlled Release 38, pp. 177-184 (1996).
Jeong et al., “Biodegradable Block Copolymers As Injectable Drug-Delivery Systems”,Nature, 1997, pp. 860-862, vol. 388, No. 28.
Martinez et al, “Branched Poly(Ethylene Glycol) Linkers”,Macromolecular Chemistry And Physics, 1997, pp. 2489-2498, vol. 198, No. 8.
Pitt et al, “Manipulation Of The Rate Of Hydrolysis Of Polymer-Drug Conjugates: The Secondary Structure Of The Polymer”,Journal Of Controlled Release, 1996, pp. 221-229, vol. 39, No. 2.
Zalipsky, “Functionalized Poly(ethylene glycol) for Preparation of Biologically Relevant Conjugates”,Bioconjugate Chem., 1995, pp. 150-165, vol. 6, No. 2.
Yang et al., “Activity and Stability of Enzymes Incorporated into Acrylic Polymers”,J. Am. Chem. Soc., 1995, pp. 4843-4850, vol. 117, No. 17.

Affiliated with

Also associated with

Rating

Degradable poly(ethylene glycol) hydrogels with controlled... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Degradable poly(ethylene glycol) hydrogels with controlled..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Degradable poly(ethylene glycol) hydrogels with controlled... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2711771