Polynucleotide encoding saliva binding protein

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 231, 530350, 435 71, 435 792, C07H 2104, C07K 1431, G01N 3353

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active

058012346

ABSTRACT:
Saliva binding protein polypeptides and DNA (RNA) of Staphylococcus aureus encoding such saliva binding protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such saliva binding protein for the treatment of infection, particularly bacterial infections. Antagonists against such saliva binding protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of saliva binding protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding saliva binding protein family and for detecting the polypeptide in host.

REFERENCES:
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Infect Immun 59: 1093-1099 (1991) Nucleotide sequence of a gene coding for a Saliva-binding protein (SsaB) from Streptococcus sanguis 12 and possible role of the protein in coaggregation with Actinomyces N. Ganeshkumar, P.M. Hannam, P.E. Kolenbrander, and B.C. McBride.
Infect Immun 63: 703-706 (1995) Cloning of an Enterococcus faecalis Endocarditis Antigen: Homology with Adhesions from Some Oral Streptococci. A.M. Lowe, P.A. Lambert, and A.W. Smith.

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