Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-15
2011-03-15
Shameem, Golam M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S125000, C548S143000, C548S250000, C548S427000, C548S439000, C514S361000, C514S381000, C514S383000, C514S410000
Reexamination Certificate
active
07906546
ABSTRACT:
The present invention relates to compounds of the formula (I)wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, n, and k are defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for in the treatment and prophylaxis of diseases which are modulated by LXRα and/or LXRβ agonists, including increased lipid and cholesterol levels, particularly low HDL-cholesterol, high LDL-cholesterol, atherosclerotic diseases, diabetes, particularly non-insulin dependent diabetes mellitus, metabolic syndrome, dyslipidemia, Alzheimer's disease, sepsis, inflammatory diseases such as colitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as Alzheimer's disease or impaired/improvable cognitive function.
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Dehmlow Henrietta
Kuhn Bernd
Masciadri Raffaello
Panday Narendra
Ratni Hasane
Hoffmann-La Roche Inc.
Johnston George W.
Megerditchian Samuel H.
Shameem Golam M
Tramaloni Dennis P.
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