Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-04-08
1998-09-01
LeGuyader, John L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 6, 435 911, 4351713, 435 325, 536 231, 536 243, 536 245, C12N 1585, A61K 4800, C12Q 168, C07H 2104
Patent
active
058011544
ABSTRACT:
Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding MRP. In a preferred embodiment, the oligonucleotide has at least one 2'-methoxyethoxy modification. Methods of preventing the development of multidrug resistance and of improving the efficacy of chemotherapy are also disclosed.
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Baracchini Edgardo
Bennett C. Frank
Dean Nicholas M.
ISIS Pharmaceuticals Inc.
LeGuyader John L.
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