Thienopyridines

Details Thienopyridines Thienopyridines

2011-08-02

2011-08-02

Wang, Shengjun (Department: 1627)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S301000

Reexamination Certificate

active

07989625

ABSTRACT:
The invention relates to novel thienopyridine derivatives of formula (I), wherein R1, R2, R3, R4 and Y have the meaning cited in claim1, are HSP90-inhibitors and can be used for producing a medicament for treating illnesses, wherein the inhibition, regulation and/or modulation of HSP90 plays a roll.

REFERENCES:
patent: WO 2005/034950 (2005-04-01), None
patent: WO 2005/058315 (2005-06-01), None
Dyachenko et al. “New route to 6-amino-4-aryl-3,5-dicyanopyridine-2(1H)-thiones,” Russian Journal of Organic Chemistry, 1997, vol. 33, No. 7, pp. 1014-1017, Abstract, CAPLUS Accession No. 1998:310476.
Registry/STN, 2002, XP002377770 Verbindungen mit den Registry-Nummern: [476319-18-3]; [476319-16-1]; [476319-13-8]; [476318-97-5]; [476318-95-3]; [476318-77-1]; [476318-75-9]; [476318-73-7]; [476318-72-6]; [476318-69-1]; [476318-50-0]; [476318-48-6]; [476318-46-4]; [476318-45-3].
Registry/STN, 2000, XP002377784 Verbindung mit der Registry Nummer: [299464-96-3].
Registry/STN, 2000, XP002377782 Verbindung mit der Registry Nummer: [309268-56-2].
Registry/STN, 2000, XP002377783 Verbindung mit der Registry Nummer: [299464-98-5].
Registry/STN, 2000, XP002377781 Verbindung mit der Registry Nummer: [309291-64-3].
Registry/STN, 2001, XP002377780 Verbindung mit der Registry Nummer: [328109-88-2].
Registry/STN, 2001, XP002377777 Verbindungen mit den Registry Nummern: [361478-01-5]; [361477-77-2].
Registry/STN, 2001, XP002377776 Verbindung mit der Registry Nummer: [372175-86-5].
Registry/STN, 2001, XP002377775 Verbindung mit der Registry Nummer: [375837-21-1].
Registry/STN, 2002, XP002377774 Verbindung mit der Registry Nummer: [383156-16-9].
Registry/STN, 2002, XP002377773 Verbindung mit der Registry Nummer, [406196-06-3].
Registry/STN, 2002, XP002377772 Verbindung mit der Registry Nummer: [406723-52-2].
Registry/STN, 2002, XP002377771 Verbindung mit der Registry Nummer: [476299-29-3].
Registry/STN, 2004, XP002377768 Verbindungen mit den Registry Nummern: [774569-16-3]; [774569-13-0]; [774569-12-9]; [774569-01-6].
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Dyachenko, V. D. et al: “New route to 6-amino-4-aryl-3, 5-dicyanopyridine-2 (1H)-thiones” XP002377767 retrieved from STN Database accession No. 1998: 310476 Verbindung mit der Registry Nummer: [208254-40-4] abstract & Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii), 33(7), 1014-1017 CODEN: RJOCEQ; ISSN: 1070-4280, 1997, XP008066978 *Scheme 1: Ivc to IXc.
Abbas A A et al: “Versatile starting materials for novel 1, .omega.-bis (pyridin-4- ylphenoxy) alkanes, and their corresponding bis (thieno [2, 3-b] pyridin-4- ylphenoxy) derivatives” CAPLUS, 1998, XP002377766 Verbindungen mit den Registry Nummern: [372187-53-6]; [372187-54-7].

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