Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Reexamination Certificate
2011-08-30
2011-08-30
Schultz, Doug (Department: 1633)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
C514S04400A, C435S006120
Reexamination Certificate
active
08007778
ABSTRACT:
Methods useful in the regulation of myocardial contraction are disclosed. The methods are useful in the regulation of heart function. The invention reveals that sorcin overexpression enhances cardiac contractile performance and establishes the concept of sorcin as a regulator of myocardial contractility. The invention also provides screening assays that allow for the identification of agents that modulate sorcin expression. Such agents are useful, for example, for diagnosing cardiac contractile function associated disorders in subjects, and treating the subjects with the agents identified as being able to modulate sorcin expression.
REFERENCES:
patent: 6335011 (2002-01-01), Podsakoff et al.
Kizana et al. Heart, Lung and Circulation 2007;16:180-184.
Seidler et al. Circ Res. 2003;93:132-139.
Fisher et al., “Overexpression of Sorcin in the Murine Heart Modulates Cardiac Performance, Circulation”, Oct. 2000, vol. 102, No. 18, p. 296, 1448.
Suarez et al., “In vivo Adenoviral Gene Transfer of Sorcin Increases Cardiac Contractility Circulation”, Nov. 2002, vol. 106, No. 19, Supp. p. 29, 144.
Suarez et al., “In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy”, Am. J. Physiol. Heart Circ. Physiol., Jan. 2004; 286(1):H68-75, Epub. Sep. 4, 2003.
Belke Darrell
Dillmann Wolfgang H.
Gloss Bernd
Suarez Jorge
DLA Piper (US) LLP
Schultz Doug
The Regents of the University of California
LandOfFree
Use of calcium binding proteins to improve cardiac... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of calcium binding proteins to improve cardiac..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of calcium binding proteins to improve cardiac... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2696171