Process for preparation of substituted sulfoxides

Details Process for preparation of substituted sulfoxides Process for preparation of substituted sulfoxides

2011-04-19

2011-04-19

Morris, Patricia L (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S210000, C544S124000

Reexamination Certificate

active

07928240

ABSTRACT:
The present invention relates to a process for preparing substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, racemic omeprazole is reacted with (S)-camphorsulfonyl chloride to form a diastereomeric mixture and the diastereomers are separated by fractional crystallization, followed by deprotection to give esomeprazole.

REFERENCES:
patent: 5984789 (1999-11-01), Reik et al.
patent: 6559167 (2003-05-01), Garst et al.
patent: 4035455 (1992-05-01), None
patent: 0221041 (1978-05-01), None
patent: 0005129 (1981-04-01), None
patent: WO 94/27988 (1994-08-01), None
patent: WO 2004/002982 (2004-01-01), None
Dorwald, Side Reactions in Organice Synthesis, 2005, Wiley: VCH Weinheim Preface, pp. 1-15 : chapter 8, pp. 279-308.
Sigrist-Nelson K, Krasso A, Muller RK. Fischli AE. Ro 18-5364, a potent new inhibitor of the gastric (H++K+)-ATPase. Eur J Biochem. Jul. 15, 1987;166(2):453-9.
PCT International Search Report Dated Apr. 28, 2004.

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