Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-08
2011-03-08
Shameem, Golam M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S300100, C548S335100, C548S343100, C514S385000, C514S397000
Reexamination Certificate
active
07902247
ABSTRACT:
A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1:whereinn=1-4;X is C or N;R1-R6can be the same or different and are independently selected from the group consisting of H, C1-6alkyl, OCH3, OH, F, Cl, Br, CH2OH, CH2N(R7)2, C(O)R8, CH2CN, CF3;wherein R7is H or C1-6alkyl; andR8is C1-6alkyl or aryl.The compounds of Formula 1 can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.
REFERENCES:
patent: 5559141 (1996-09-01), Karjalainen et al.
patent: 6313172 (2001-11-01), Chow et al.
patent: 0 390 558 (1994-09-01), None
patent: 1499485 (1978-02-01), None
patent: 2101114 (1983-01-01), None
patent: WO99/28300 (1999-06-01), None
patent: WO01/00586 (2001-01-01), None
patent: WO02/076950 (2002-10-01), None
patent: WO2007/085556 (2007-08-01), None
Galley et al (2007): STN International HCAPLUS database, (Columbus, Ohio), Accession No. 2007:845761.
Karjalainen et al (2000): STN International HCAPLUS database, (Columbus, Ohio), Accession No. 2000:505881.
Robert R. Ruffolo, Jr., Alpha-Adrenoreceptors: Molecular Biology, Biochemistry and Pharmacology, (Progress in Basic and Clinical Pharmacology series, Karger, 1991).
Messier et al, Pharmacol. Toxicol. 76, pp. 308-311-1995.
Conklin et al, Nature 363: pp. 274-6-1993.
“Prodrugs and Drug Delivery Systems,” which is a chapter in Richard B. Silverman,Organic Chemistry of Drug Design and Drug Action, 2d Ed., Elsevier Academic Press: Amsterdam, 2004, pp. 497-557.
Bhat Smita S.
Chow Ken
Garst Michael E.
Heidelbaugh Todd M.
Sinha Santosh C.
Allergan Inc.
Ene Doina G.
Forrestal Kevin J.
Shameem Golam M
Wurst John E.
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