Use of heterocyclic compounds as SCCE inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Hydrocarbon doai

Reexamination Certificate

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C514S222800, C424S400000

Reexamination Certificate

active

07872052

ABSTRACT:
The present invention relates to heterocyclic inhibitors of stratum corneum chymotryptic enzyme (SCCE). More particularly, the invention relates to the use of compounds with the formula (I) or (II) for treatment of certain diseases, in particular skin diseases such as pruritus, as well as cancer such as ovarian cancer.

REFERENCES:
patent: 4251531 (1981-02-01), Doria et al.
patent: 5073559 (1991-12-01), Coates
patent: 5346886 (1994-09-01), Lezdey et al.
Gilmore et al, Synthesis and Evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as Clr serine protease inhibitors, Bioorganic & Medicinal Chemistry Letters, 1996, 6(6), 679-682.
http://www.merck.com/mmpe/sec10/ch116/ch116b.html (accessed Mar. 20, 2008).
M. Mordarski, et al., “Antitumor properties of 1,3-oxazine derivatives. Derivatives of Dihydro-1,3-Oxazine Condensed with an Aromatic Ring in Position 5,6”Archivum Immunologiae et Therapiae Experimentalis, 1971, 19(4):533-545.
V. Pavlidis, et al., “The Synthesis of a Novel Series of Substituted 2-Phenyl-4H-3,1-benzoxazin-4-ones,”Synth. Commun., 1994, 24(4):533-548.
R. Law et al., “An Overview of the Serpin Superfamily,”Genome Biology, 2006, 7:216-216;11.
D. Curiel et al., “Serum α1—Antitrypsin Deficiency Associated with the Common S-type (Glu264→Val) Mutation Results from Intracellular Degradation of α1—Antitrypsin Prior to Secretion,” TheJournal of Biological Chemistry, 1989, vol. 264, No. 18, Issue of Jun. 25, 10477-10486.
Peter G. W. Gettins, “Serpin Structure, Mechanism, and Function,” Chem. Rev., 2002, 102, 4751-4803.

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