Process for preparing cephalosporins with penicillin acylase wit

Details Process for preparing cephalosporins with penicillin acylase wit Process for preparing cephalosporins with penicillin acylase wit

1996-01-18

1998-09-01

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435 43, 435195, 435230, 435231, C12P 3500

Patent

active

058010114

ABSTRACT:
The invention relates to an improved process for preparing cephalosporins by reaction compounds such as 7-amino-cephalosporanic acid, 7-amino-3-deacetoxy-cephalosporanic acid or their derivatives with derivatives of .alpha.-amino acids in the presence of a properly immobilized penicillin acylase enzyme under the following conditions, independently, or in combination: (1) at a temperature ranging from 0.degree. C. to +20.degree. C.; or (2) at ambient pH; with a high molar ratio of .alpha.-amino acid to a cephalosporanic nucleus.

REFERENCES:
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Savidge, Drugs and Pharm. Sci., 22, 171-224 (1984).
Takahashi et al., Journal of the Amer. Chem. Soc., 94, No.11, 4035-4037, (1972).
Okachi et al., Enzyme Eng., 6, 81-90 (1982).
Baldaro, "Effect of Temperature on Enzymatic Synthesisof Cephalosporins", Bioorg. Chem. in Healthcare and Technology, vol. 207, pp. 237-240 (1991).
Marconi et al, Agric Biol. Chem., vol. 39 (1) pp. 277-280, 1975.
Choi et al, Biotechnol. Bioeng., 1981, vol. 23 pp.361-371.

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