Quinoline derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S153000

Reexamination Certificate

active

07923457

ABSTRACT:
The invention relates to compounds represented by Formula (I):and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R3-8, X3, X5, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).

REFERENCES:
patent: 3376195 (1968-04-01), Allais et al.
patent: 3755332 (1973-08-01), Wasley et al.
patent: 3936461 (1976-02-01), Schwender et al.
patent: 4421920 (1983-12-01), Baudouin et al.
patent: 4764454 (1988-08-01), Ichijima et al.
patent: 5792783 (1998-08-01), Tang et al.
patent: 5834504 (1998-11-01), Tang et al.
patent: 5883113 (1999-03-01), Tang et al.
patent: 5886020 (1999-03-01), Tang et al.
patent: 6071935 (2000-06-01), Lyssikatos
patent: 6143764 (2000-11-01), Kubo et al.
patent: 6225318 (2001-05-01), Sobolov-Jaynes et al.
patent: 6492383 (2002-12-01), Munchhof et al.
patent: 6797823 (2004-09-01), Kubo et al.
patent: 7381824 (2008-06-01), Hong et al.
patent: 2004/0053908 (2004-03-01), Funahashi et al.
patent: 2004/0132727 (2004-07-01), Sakai et al.
patent: 2004/0209905 (2004-10-01), Kubo et al.
patent: 2005/0049264 (2005-03-01), Miwa et al.
patent: 2005/0187236 (2005-08-01), Tsuruoka et al.
patent: 0326330 (1989-08-01), None
patent: 0602851 (1994-06-01), None
patent: 1086705 (2001-03-01), None
patent: 0 860 433 (2002-07-01), None
patent: 1251130 (2002-10-01), None
patent: 1 447 405 (2004-08-01), None
patent: 1 522 540 (2005-04-01), None
patent: 1548008 (2005-06-01), None
patent: 2.077.455 (1969-09-01), None
patent: 11-158149 (2002-09-01), None
patent: WO92/21660 (1992-12-01), None
patent: WO93/03030 (1993-02-01), None
patent: WO93/13097 (1993-07-01), None
patent: WO95/15758 (1995-06-01), None
patent: WO95/19970 (1995-07-01), None
patent: WO95/21613 (1995-08-01), None
patent: WO95/23141 (1995-08-01), None
patent: WO96/09294 (1996-03-01), None
patent: WO96/15118 (1996-05-01), None
patent: WO96/30347 (1996-10-01), None
patent: WO96/40142 (1996-12-01), None
patent: WO97/03069 (1997-01-01), None
patent: WO97/13771 (1997-04-01), None
patent: WO97/17329 (1997-05-01), None
patent: WO97/22596 (1997-06-01), None
patent: WO97/32856 (1997-09-01), None
patent: WO97/49688 (1997-12-01), None
patent: WO98/02437 (1998-01-01), None
patent: WO98/02438 (1998-01-01), None
patent: WO98/13350 (1998-04-01), None
patent: WO98/23613 (1998-06-01), None
patent: WO98/37079 (1998-08-01), None
patent: WO98/50356 (1998-11-01), None
patent: WO98/51344 (1998-11-01), None
patent: WO98/54093 (1998-12-01), None
patent: WO99/10349 (1999-03-01), None
patent: WO99/16755 (1999-04-01), None
patent: WO99/24440 (1999-05-01), None
patent: WO99/61422 (1999-12-01), None
patent: WO 00/18761 (2000-04-01), None
patent: WO 00/35919 (2000-06-01), None
patent: WO00/38665 (2000-07-01), None
patent: WO00/43366 (2000-07-01), None
patent: WO 00/47212 (2000-08-01), None
patent: WO 00/50405 (2000-08-01), None
patent: WO01/47890 (2001-07-01), None
patent: WO01/47931 (2001-07-01), None
patent: WO01/70268 (2001-09-01), None
patent: WO01/74296 (2001-10-01), None
patent: WO01/74360 (2001-10-01), None
patent: WO01/85796 (2001-11-01), None
patent: WO 02/12226 (2002-02-01), None
patent: WO02/30453 (2002-04-01), None
patent: WO 02/30925 (2002-04-01), None
patent: WO 02/32872 (2002-04-01), None
patent: WO02/41882 (2002-05-01), None
patent: WO02/064170 (2002-08-01), None
patent: WO03/006059 (2003-01-01), None
patent: WO 03/033472 (2003-04-01), None
patent: WO03/035047 (2003-05-01), None
patent: WO 03/074529 (2003-09-01), None
patent: WO 2004/018430 (2004-03-01), None
patent: WO 2004/020434 (2004-03-01), None
Abuzar, S., CA 105:42720, abstract only of Indian Journal of Chemistry, Section B; Organic Chem include Med Chem, Col. 24B(8), pp. 848-852, 1985.
Bussolino, F. et al. “Role of Soluble Mediators in Angiogenesis,”European Journal of Cancer, 1996, 32A:14, 2401-2412.
Chemical Abstract Accession No. 1981:407199. [Agrawal, V. et al., “Studies in Potential Filaraicides: Part XI. Synthesis of 2-(Dialkylaminomethyl)-4-Substituted Aminophenols aAs Amodiaquine Analogs,”Indian Journal of Chemistry, Section B, 1981, 95:1, 68682.].
Chemical Abstract Accession No. 1969:68193. [Hamana, et al., “4-Substituted Quinoline Derivatives,”Japan Tokkyo Koho, 1969, 70:15, 366.].
Chemical Abstract Accession No. 1994:217227. [Barlin, G. et al., “Potential Antimalarials. XVIII. Some Mono- and Di-Mannich Bases of 3-[7-Chloro(and Trifluoromethyl)Quinolin-4-ylamino]Phenol,”Australian Journal of Chemistry, 1993, 46:11, 1685-93.].
Deplanque, G. et al. “Anti-angiogenic Agents: Clinical Trial Design and Therapies in Development,”European Journal of Cancer, 2000, 36, 1713-1724.
Firsching, A. et al. “Antiproliferative and Angiostatic Activity of Suramin Analogues,”Cancer Research, 1995, 55, 4957-4961.
Folkman, A. et al. “New Perspectives in Clinical Oncology From Angiogenesis Research,”European Journal of Cancer, 1996, 32A:14, 2534-2539.
Gibson, K. H., CA 133:350152, abstract only of WO 2000/068200, Nov. 2000.
Gravatt, G. et al., “DNA-Directed Alkylating Agents. 4. 4-Anilinoquinoline-Based Minor Groove Directed Aniline Mustards,”Journal of Medicinal Chemistry, 1991, 34, 1552-1560.
Henniquin, L.F., CA 136:178717, abstract only of WO 2002/12226, Feb. 2002.
Kotva, R. et al. “Substances With Antineoplastic Activity. LIII.* N-{δ-(4-Pyrrolo[2,3-d]Pyrimidinylthio)Valeryl}Amino Acids and Analogous Derivatives of Di- and Triglycine,”Collection Czechoslov ChemicalCommun, 1973, 38:5, 1438-1444.
Rewcastle, G. et al. “Tyrosine Kinase Inhibitors. 5. Synthesis and Structure-Activity Relationships for 4-[(Phenylmethyl)Amino]- and 4-(Phenylamino)Quinazolines as Potent Adenosine 5]-Triphosphate Binding Site Inhibitors of the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor,”Journal of Medicinal Chemistry, 1995, 38, 3482-3487.
Spacey, G. et al. “Indolocarbazoles Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Autophosphorylation,”Biochemical Pharmacology, 1998, 55, 261-271.
Wang, F. et al., “A Convenience Set of Bidentate Pyridine Ligands for Combinatorial Synthesis,”Tetrahedron Letters 40, 1999, 4779-4782.
Aiello, L., et al., “Role of Vascular Endothelial Growth Factor in Diabetic Vascular Complications,”Kidney International, 2000, S-113-S119, vol. 58, No. 77.
Eckhardt, S., et al., “Development of Angiogenesis Inhibitors for Cancer Therapy,”Investigational New Drugs, 1997, 1-3, vol. 15.
Ferrara, N., et al., “The Biology of VEGF and its Receptors,”Nature Medicine, 2003, 669-676, vol. 9, No. 6.
Fong, T., et al., SU5416 is a Potent and Selective Inhibitor of the Vascular Endothelial Growth Factor Receptor (FLK-1/KDR) That Inhibits Tyrosine Kinase Catalysis, Tumor Vascularization, and Growth of Multiple Tumor Types,Cancer Research, 1999, 99-106, vol. 59.
O'Reilly, M., “The Preclinical Evaluation of Angiogenesis Inhibitors,”Investigational New Drugs, 1997, 5-13, vol. 15.
Parast, C., et al., “Characterization and Kinetic Mechanism of Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase (VEGFR2 TK), A Key Enzyme in Angiogenesis,”Biochemistry, 1998, 16788-16801, vol. 37.
Wedge, S., et al., “ZD6474 Inhibits Vascular Endotheilial Growth Factor Signaling Angiogenesis, and Tumor Growth Following Oral Administration,”Cancer Research, 2002, 4645-4655, vol. 62.

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