Intermediates for the production of optically active...

Details Intermediates for the production of optically active... Intermediates for the production of optically active...

2011-08-09

2011-08-09

Young, Shawquia (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07994344

ABSTRACT:
A process for producing an optically active compound represented by formula (4) or a salt thereof:the process including reacting a cyclization reagent with an optically active compound represented by formula (3) or its salt:optionally in the presence of a Lewis acid, to form the compound of formula (4) or its salt, wherein, in the compounds of formula (3) and formula (4) and their salts, R1is a protecting group, and wherein the cyclization reagent is prepared from a titanium (IV) reagent and an alkylmetal compound.

REFERENCES:
patent: 5849757 (1998-12-01), Takemura et al.
patent: 0 266 922 (1988-05-01), None
patent: 1-139577 (1989-06-01), None
patent: 8-277284 (1996-10-01), None
patent: WO96/23782 (1996-08-01), None
patent: WO 96/39407 (1996-12-01), None
patent: 00/56718 (2000-09-01), None
patent: 02/40478 (2002-05-01), None
patent: WO 2006/012443 (2006-02-01), None
Christophe Laroche, et al., “Titanium-mediated synthesis of bicyclic cyclopropylamines from unsaturated nitriles”, Tetrahedron Letters, vol. 44, 2003, pp. 2485-2487.
Philippe Bertus, et al., “Ti (II)-Mediated Conversion of a-Heterosubstituted (O, N, S) Nitriles to Functionalized Cyclopropylamines. Effect of Chelation on the Cyclopropanation Step”, J. Org. Chem., vol. 67, 2002, pp. 3965-3968.
Philippe Bertus, et al., “Ti-Mediated Chemoselective Conversion of Cyanoesters and Cyanoamides into β-Aminoesters and 1-Aza-spirolactams Bearing a Cyclopropane Ring”, Letter, Synlett, No. 2, ISSN 0936-5214, 2003, pp. 265-267.
Stefan Wiedemann, et al., “Primary 1-Arylcyclopropylamines from Aryl Cyanides with Diethylzinc and Titanium Alkoxidest†”, Organic Letters, vol. 5, No. 5, 2003, pp. 753-755.
Kobayashi, Takashi et al., “Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. II. Synthesis and Antihypertensive Effects of 2-Amino-1, 4-dihydropyridine Derivatives Having N, N-Dialkylaminoalkoxycarbonyl Groups at 3-and/or 5-Position”, Chem. Pharm. Bull., vol. 43, No. 5, pp. 797-817, 1995.
Inagaki, Hiroaki et al., “Synthesis and Structure-Activity Relationships of 5-Amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic Acid Antibacterials Having Fluorinated 7-[(3R)-3-(1-Aminocyclopropan-1-y1]pyrrolidin-1-yl] Substituents”, J. Med. Chem., vol. 46, No. 6, pp. 1005-1015, 2003.

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