Preventive agent/remedial agent for constipation predominant...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S114000

Reexamination Certificate

active

07897614

ABSTRACT:
A novel preventive and/or therapeutic medicament for a constipation predominant IBS which contains as the active ingredient a thieno[3,2-b]pyridinecarboxamide derivative represented by the formula (I):wherein R1and R2each independently represents hydrogen atom or a lower alkyl group and A represents a substituent selected from the group consisting of 1-azabicyclo[3.2.2]nonyl group 1-azabicyclo[2.2.2]octyl group, and the N-oxides thereof, a pharmaceutically acceptable salt thereof, or a solvate or hydrate thereof.

REFERENCES:
patent: 5352685 (1994-10-01), Maruyama et al.
patent: 0 560 348 (1993-09-01), None
patent: 08-286450 (1996-04-01), None
patent: 8/143573 (1996-06-01), None
patent: 01/37824 (2001-05-01), None
patent: 01/58898 (2001-08-01), None
Irritable Bowel Syndrome (IBS) by International foundation for Functional Gastrointestinal Disorders, Nov. 2007.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
About GI Motility , Jun. 26, 2008 , International foundation of funtional Gastrointestinal Disorders by IFFGD.
Revel et al., Drugs of the Future, “MKC-733: Treatment of GERD Treatment of Constipation 5-HT3Receptor Agonist” 1999, 24(9), pp. 966-968, and corresponding abstract.
U.S. Appl. No. 10/203,278, Jul. 10, 2003.
Bueno et al., “Gastrointestinal Pharmacology: Irritable Bowel Syndrome”, Current Opinion in Pharmacology, 2005, 5:583-588.

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