Isolated nucleic acid duplex for reducing huntington gene...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C514S04400A

Reexamination Certificate

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07902352

ABSTRACT:
Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates includingMacaca mulattaandHomo sapiens. These sequences, molecules and methods aid in the study of the pathogenesis of HD and can also provide a treatment for this disease by reducing HD mRNA without causing death, locomotor impairment or cellular alterations of theMacaca mulattaandHomo sapiens.

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