Methods for identifying compounds that modulate T1R1/T1R3...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007200, C435S069100, C435S252300, C435S320100, C435S325000, C435S471000, C530S350000

Reexamination Certificate

active

07910322

ABSTRACT:
Methods for identifying compounds that modulate the T1R1/T1R3 umami taste receptors are provided. These methods comprise screening one or more compounds in a binding assay which identifies compounds that specifically bind to a T1R1/T1R3 taste receptor or which specifically modulate the specific binding of another compound to a T1R1/T1R3 taste receptor, and identifying compounds that elicit or modulate T1R1/T1R3 taste.

REFERENCES:
patent: 5993778 (1999-11-01), Firestein et al.
patent: 6383778 (2002-05-01), Zuker et al.
patent: 6540978 (2003-04-01), Margolskee et al.
patent: 6955887 (2005-10-01), Adler et al.
patent: 7022488 (2006-04-01), Servant et al.
patent: 7208290 (2007-04-01), Li et al.
patent: 7223551 (2007-05-01), Adler et al.
patent: 7241880 (2007-07-01), Adler et al.
patent: 7244584 (2007-07-01), Zucker et al.
patent: 7244835 (2007-07-01), Adler et al.
patent: 7294474 (2007-11-01), Zoller et al.
patent: 7297543 (2007-11-01), Zoller et al.
patent: 7297772 (2007-11-01), Zoller et al.
patent: 7301009 (2007-11-01), Zoller et al.
patent: 7303886 (2007-12-01), Zoller et al.
patent: 7309577 (2007-12-01), Zoller et al.
patent: 7344859 (2008-03-01), Zoller et al.
patent: 7364903 (2008-04-01), Zoller et al.
patent: 7368285 (2008-05-01), Zoller et al.
patent: 7402400 (2008-07-01), Zucker et al.
patent: 7419791 (2008-09-01), Adler et al.
patent: 7435552 (2008-10-01), Adler et al.
patent: 7452685 (2008-11-01), Adler et al.
patent: 7465550 (2008-12-01), Zucker et al.
patent: 7507544 (2009-03-01), Adler et al.
patent: 2002/0051997 (2002-05-01), Zuker et al.
patent: 2002/0094551 (2002-07-01), Adler et al.
patent: 2002/0151052 (2002-10-01), Chaudhari et al.
patent: 2002/0160424 (2002-10-01), Adler et al.
patent: 2002/0168635 (2002-11-01), Zuker et al.
patent: 2003/0008344 (2003-01-01), Adler et al.
patent: 2003/0022278 (2003-01-01), Zuker et al.
patent: 2003/0022288 (2003-01-01), Zuker et al.
patent: 2003/0036089 (2003-02-01), Wei et al.
patent: 2003/0040045 (2003-02-01), Zuker et al.
patent: 2003/0054448 (2003-03-01), Adler et al.
patent: 2003/0166137 (2003-09-01), Zuker et al.
patent: 2004/0086877 (2004-05-01), Lal et al.
patent: 2005/0106571 (2005-05-01), Erlenbach et al.
patent: 2007/0105159 (2007-05-01), Erlenbach et al.
patent: WO 95/08627 (1995-03-01), None
patent: WO 00/06592 (2000-02-01), None
patent: WO 00/06593 (2000-02-01), None
patent: WO 01/64882 (2001-09-01), None
patent: WO 01/66563 (2001-09-01), None
patent: WO 01/83749 (2001-11-01), None
patent: WO 02/064631 (2002-08-01), None
patent: WO 03/001876 (2003-01-01), None
patent: WO 03/025137 (2003-03-01), None
patent: WO 2005/015158 (2005-02-01), None
Adler, E. et al., “A Novel Family of Mammalian Taste Receptors”, Cell, vol. 100, No. 6, p. 693-702, Mar. 17, 2000.
Alexander, et al., “Altering the Antigenicity of proteins”, Proc. Natl. Acad. Sci. USA, vol. 89, p. 3352-3356, Apr. 1992.
Bönigk, W., et al., “The Native Rat Olfactory Cyclic Nucleotide-Gated Channel is Composed of Three Distinct Subunits”, The Journal of Neuroscience, vol. 19, No. 136, p. 5332-5347, Jul. 1, 1999.
Bowie, et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions”, Science, vol. 247, p. 13061310, Mar. 16, 1990.
Damak, S., “Detection of Sweet and Umani Taste in the Absence of Taste Receptor T1r3,” vol. 301, pp. 850-853, 2003.
Guo, et al., “Protein Tolerance to Random Amino Acid change”, PNAS, vol. 101, No. 25, p. 9205-9210, Jun. 22, 2004.
Hoon, et al., “Putative Mammalian Taste Receptors: A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity”, Cell, vol. 96, p. 541-551, Feb. 19, 1999.
Johnson, C., et al., “The Effect of the Sweetness Inhibitor 2(-4-methoxyphenoxy) propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli”, Chemical Senses, vol. 19, No. 4, p. 349-358, 1994.
Kinnamon, S. and Cummings, T., “Chemosensory Transduction Mechanisms in Taste”, Annu. Rev. Physoil., vol. 54, p. 715-731, 1992.
Kitagawa, M., et al., “Molecular Genetic Identification of a Candidate Receptor Gene for Sweet Taste”, Biochemical and Biophysical Research Communications, vol. 283, p. 236-242, 2001.
Krautwurst, et al., “Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library”, Cell, vol. 95, p. 917-926, Dec. 23, 1998.
Li, X., et al., “Human Receptors for Sweet and umami taste”, Proceeding of the National Academy of Science, vol. 99, No. 7, p. 4692-4696, Apr. 2, 2002.
Lindemann, “A Taste for Umami”, Nature Neuroscience, ol. 3, No. 2, p. 99-100, Feb. 2000.
Max, M., et al., “Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac”, Nature Genetics, vol. 28, p. 58-63, May 2001.
Montmayeur, J.P., et al., “A Candidate Taste Receptor Gene Near a Sweet Taste Locus”, Nature Neuroscience, vol. 4, No. 5, May 2001.
Nelson, et al., “An Amino-acid Taste Receptor”, Nature, vol. 416, p. 199-202, Mar. 14, 2002.
Nelson, et al., “Mammalian Sweet Taste Receptors”, Cell, vol. 106, p. 381-390, Aug. 10, 2001.
Perruccio, et al., “Possible Role for gustducin in Taste Transduction in Hirudo Medicinalis”, Society for Neuroscience Abstracts, vol. 26, No. 1-2, Abstract No. 66.15, 2000.
Sainz, E., et al., “Identification of a Novel Member of the T1R family of putative taste receptors”, Journal of Neurochemistry, vol. 77, p. 896-903, 2001.
Temussi, P., et al., “The history of sweet taste: not exactly a piece of cake”, Journal of Molecular Recognition, 2006, 19: 188-199.
Waterston, R.H. “Direct Submission”, Genome Sequencing Center, Apr. 21, 2000—XP002262036.
Database EMBL ′Online!, embl heidelberg; Acc#: Ac062024, Jun. 21, 2000.
GenBank Accession No. AA907022, May 19, 1998.
GenBank Accession No. AL139287, clone RP5-89003, Feb. 13, 2000.
European Search Report for European Application No. 08153652.6, dated Jan. 21, 2009.
Extended European Search Report and Opinion for European Application No. 08075748.7, dated Nov. 21, 2008.

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