MHC class II epitopes of 5T4 antigen

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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C424S193100, C514S002600, C530S326000

Reexamination Certificate

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07910109

ABSTRACT:
There is provided an MHC class II peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the minimal epitope from the amino acid sequence shown as SEQ ID No. 2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No. 3; (iii) a minimal epitope from the region 281-420 of 5T4. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease.

REFERENCES:
patent: 4558035 (1985-12-01), Johnson
patent: 5118672 (1992-06-01), Schinazi et al.
patent: 5356779 (1994-10-01), Mozes et al.
patent: 5869053 (1999-02-01), Stern et al.
patent: 0110385 (1984-06-01), None
patent: 0198328 (1986-10-01), None
patent: 1152060 (2001-11-01), None
patent: 2370571 (2002-07-01), None
patent: WO89/07947 (1989-09-01), None
patent: WO98/03568 (1992-03-01), None
patent: WO97/19183 (1997-05-01), None
patent: WO99/15683 (1999-04-01), None
patent: WO99/15684 (1999-04-01), None
patent: WO 00/29428 (2000-05-01), None
patent: WO 01/00225 (2001-01-01), None
Bodey, B et al. Anticancer Research [2000] 20:2665-2676.
Marchand, M et al. Int. J. Cancer [1999] 20:219-230.
Marchand, M et al. Exp. Opin. Biol. Ther. [2001] 1(3):497-510.
Myers et al (J. Biol. Chem. 269:9319-9324, 1994).
Farrar and Schrieber (Ann. Rev. Immunol. 1993, p. 580).
Guschlbauer, et al. “Poly-2′-deoxy-2′-fluoro-cytidylic acid: enzymatic synthesis, spectroscopic characterization and interaction with poly-inosinic acid”,Nucleic Acids Res.(1997) 4:1933.
Schibahara, et al. “Site-directed cleavage of RNA”,Nucleic Acids Res.(1987) 15:4403.
Gershon, et al. “The nucleotide sequence around the capripoxvirus thymidine kinase gene reveals a shared specifically with leporipoxvirus”,J. Gen. Virol,(1989) 70:525.
Weir, et al. “Nucleotide sequence of the vaccinia virus thymidine kinase gene and the nature of spontaneous frameshift mutations”,J. Virol.(1983) 46:530.
Esposito, et al. “Nucleotide sequence of the thymidine kinase gene region of monkeypox and variola viruses”,Virology(1984) 135:561.
Kilpatrick, et al. “Cloning and physical mapping of yada monkey tumor virus DNA”Virology(1985) 143:399.
Binns, et al. “Comparison of a conserved region in fowlpox virus and caccinia virus gnomes and the translocation of the fowlpox virus thymidine kinase gene”,J. Gen Virol(1988) 69:1275.
Schnitzlein, et al. “A rapid method for identifying the thymidine kinase genes of avipoxviruses”,J. Virological Method(1988) 23:341.
Fathi, et al. “Efficient targeted insertion of an unselected marker into the vaccinia virus genome”,Virology(1986) 97:105.
Graham, et al. “A new technique for the assay of infectivity of human adenovirus 5 DNA”,Virol.(1973) 52:456-467.
Straubinger, et al. “Liposomes as carriers of intracellular delivery of nucleic acids”,Methods in Enzymology,(1983) 101:512-527.
Studier, et al. “Use of T7 RNA polymerase to direct expression of cloned genes”,Methods in Enzymol.(1990) 185:60-89.
Matthias, et al. “Eukaryotic expression vectors for the analysis of mutant proteins”,NAR(1989) 17:6418.
Wootton & Federhen, “Statistics of local complexity in amino acid sequences and sequence databases”,Computers and Chemistry(1993) 17:149-163.
Myers, et al. “Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein”,J. Biol. Chem.(1994) 169:9319-9324.
Starzynska, et al. “The expression of 5T4 antigen in colorectal and gastic carcinoma”,Br. J. Cancer(1992) 66(5):867-869.
Starzynska, et al. “Prognostic significance of 5T4 oncofetal antigen expression in colorectal”Br. J. Cancer(1994) 69(5):899-902.
Hobbs, et al. “Polynucleotides containing 2′-amino-2′-deoxyribose and 2′azido-2′-deoxyribose”,Biochemistry(1973) 12:5138.
Starzynska, et al. “5T4 oncofetal antigen in gastric carcinoma and its clinical significance”,Eur J. Gastroenterol Hepatol(1998) 10(6)479-484.
Carsberg, et al. “Metastasis-associated 5T4 antigen disrupts cell-cell contacts and induces cellular motilityin epithelial cells”,Int. J. Cancer(1996) 68(1):84-92.
Yewdell, et al. “TAP-independent delivery of antigenic peptides to the endoplasmic reticulum: therapeutic potential and insights into TAP-dependent antigen processing”,J. Immunotherapy(1998) 21:127-31.
Calvert, et al. “Fowlpox virus recombinants expressing the envelope glycoprotein of an avian reticuloendotheliosis retrovirus induce neutralizing antibodies and reduce viremia in chickens”,J. of Virol.(1993) 67:3069-3076.
Carroll, et al. “Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen”,J. Natl. Cancer Inst.(1998) 90(24):1881-1887.
Carroll, et al. “Two bright new faces in gene therapy”,Nature Biotechnology(1996) 14:556.
Pieken, et al. “Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes”,Science(1991) 253:314-317.
Parker, et al. “Scheme for ranking potential HLA-A2 binding peptides based on indpendent binding of individual peptide side-chains”,J. Immunol.(1994) 152:163-175.
Fu, et al. “An endoplasmic reticulum-targeting signal sequence enhances the immunogenicity of an immunorecessive simian virus 40 large T antigen cytotoxic T-lymphocyte epitope”,J. Virol.(1998) 72:1469-81.
Schödel, et al. “Hepatitis B virus core and e antigen: immune recognition and use as a vaccine carrier moiety”,Intervirology(1996) 39:104-10.
Wolff and Trubetskoy “The cambrian period of nonviral gene delivery”,Nature Biotechnology(1998), 16:421-423.
Taylor, et al. “Biological and immunogenic properties of a canarypox-rabies recombinant, ALVAC-RG (vCP65) in non-avian species”,Vaccine(1998) 79:1637-46.
Stannard, et al. “Evidence for incomplete replication of a penquin poxvirus in cells of mammalian origin”,J. Gen. Virol.(1998) 79:1637-46.
Mackett, et al. “Vaccinia virus: a selectable eukaryotic cloning and expression vector”,PNAS(1982) 79:7415-7419.
Upton, et al. “Identification and nucleotide sequence of the thymidine kinase gene of shope fibroma virus”,J. Virology(1986) 60:920.
Boyle, et al. “Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinase”,Virology(1987) 156:355-365.
Lewis, et al. “Human immunodeficiency virus infection of cells arrested in the cell cycle”EMBO J.(1992) 11:3053-3058.
Lewis and Emerman, “Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus”,J. Virol.(1994) 68:510-516.
Mackett, et al. “General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes”,J. Viral.(1984) 49:857-864.
Hruby, et al. “Fine structure analysis and nucleotide sequence of the vaccinia virus thymidine kinase gene”,PNAS(1983) 80:3411-3415.
Lytvyn, et al. “Comparison of the thymidine dinase genes from three entompoxiruses”,J. Gen Viral,(1992) 73:3235-3240.
Smith, et al. “Vaccinia virus immune evasion”,Immunol Rev.(1997) 159:137-154.
Jenkins, et al. “Formation of lentivirus particles by mammalian cells infected with recombinant fowlpox virus”,AIDS Research and Human Retroviruses(1991) 7:991-998.
Taylor, et al. “Recombinant fowlpox virus inducing protective immunity in non-avian species”,Vaccine(1988) 6:497-503.
Sphener, et al. “Insertion of the fusion gene from Newcastle disease virus into a non-essential region in the terminal repeats of fowlpox virus and demonstration of protective immunity induced by the recombinant”,J.

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