Method involving 1-benzotriazolyl carbonate esters of polymers

Details Method involving 1-benzotriazolyl carbonate esters of polymers Method involving 1-benzotriazolyl carbonate esters of polymers

2011-07-12

2011-07-12

Nutter, Nathan M (Department: 1765)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

C525S365000, C525S377000, C525S403000, C525S406000, C525S056000, C525S060000

Reexamination Certificate

active

07977427

ABSTRACT:
The invention provides a method comprising the steps of (i) reacting a water-soluble and non-peptidic polymer having two or more terminal hydroxyl groups with di(1-benzotriazolyl)carbonate to form a water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups; and (ii) reacting the water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups with a water-soluble and non-peptidic polymer having three or more primary amino groups under conditions effective to form a cross-linked polymer composition.

REFERENCES:
patent: 5281698 (1994-01-01), Nitecki
patent: 5629384 (1997-05-01), Veronese et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 5985263 (1999-11-01), Lee et al.
patent: 6348558 (2002-02-01), Harris et al.
patent: 6376604 (2002-04-01), Kozlowski
patent: 6436386 (2002-08-01), Roberts et al.
patent: 6624246 (2003-09-01), Kozlowski
patent: 6710125 (2004-03-01), Kozlowski
patent: 7101932 (2006-09-01), Kozlowski
patent: 7378469 (2008-05-01), Kozlowski
patent: 7544738 (2009-06-01), Kozlowski
patent: 2009/0215910 (2009-08-01), Kozlowski
patent: 287951 (1991-03-01), None
Monfardini, et al., “A Branched Monomethoxypoly(ethylene glycol) for protein modification”, Bioconj. Chem. J. of Amer. Chem. Soc., vol. 6, No. 1, pp. 62-69, (1995).
Shearwater Polymers, Inc., Polyethylene Glycol and Derivatives, pp. 1-53, (Catalog—Jul. 1997).
Shearwater Polymers, Inc., Polyethylene Glycol and Derivatives: Functionalized Biocompatible Polymers for Research and Pharmaceuticals, pp. 1-50, (Catalog—Jan. 2000).
International Search Report, corresponding to International Application No. PCT/US00/34590, mailed on Dec. 19, 2001.
Written Opinion, corresponding to International Application No. PCT/US00/34590, mailed on May 21, 2002.
International Preliminary Examination Report, corresponding to International Application No. PCT/US00/34590, mailed on Jul. 16, 2002.
Greenwald, et al., “Highly Water Soluble Taxol Derivatives: 7-Polyethylene Glycol Carbamates and Carbonates”, J. Org. Chem., vol. 60, pp. 331-336, (1995).
Miron, et al., “A Simplified Method for the Preparation of Succinimidyl Carbonate Polyethylene Glycol for Coupling to Proteins”, Bioconj. Chem., vol. 4, pp. 568-569, (1993).
Zalipsky, “Functionalized Poly(ethylene glycol) for Preparation of Biologically Relevant Conjugates”, Bioconj. Chem., vol. 6, pp. 150-165, (1995).
Fluka Catalog, Cover Sheet and p. 490, (1995/96).
Opposition Brief Against EP 1 259 563 B1 (English Translation).

Affiliated with

Also associated with

Rating

Method involving 1-benzotriazolyl carbonate esters of polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method involving 1-benzotriazolyl carbonate esters of polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method involving 1-benzotriazolyl carbonate esters of polymers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2681541