Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-08-02
2011-08-02
Ouspenski, Ilia (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07989173
ABSTRACT:
Soluble H4 (sH4) levels have been discovered to correlate with the stage or severity of inflammatory disorders including autoimmune disorders. In particular, circulating levels of sH4 can be used as a diagnostic for determining the severity of an inflammatory disorder or the propensity for developing an inflammatory disorder. The severity of an inflammatory disorder can be determined by assaying the levels of sH4 in a subject and comparing the levels of sH4 to reference sH4 concentrations that correlate to specific stages of an inflammatory disorder. The therapeutic efficacy of treatments for inflammatory disorders can also be determined by comparing levels of sH4 before and during treatment. Methods and devices for measuring sH4 are also provided.
REFERENCES:
patent: 3840513 (1974-10-01), Umezawa et al.
patent: 4272398 (1981-06-01), Jaffe
patent: 4376110 (1983-03-01), David et al.
patent: 4634664 (1987-01-01), Oestberg
patent: 4634666 (1987-01-01), Engleman et al.
patent: 4650764 (1987-03-01), Temin
patent: 4704692 (1987-11-01), Ladner
patent: 4769330 (1988-09-01), Paoletti et al.
patent: 4853871 (1989-08-01), Pantoliano et al.
patent: 4861627 (1989-08-01), Mathiowitz et al.
patent: 4861719 (1989-08-01), Miller
patent: 4925673 (1990-05-01), Steiner et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5120727 (1992-06-01), Kao et al.
patent: 5124263 (1992-06-01), Temin et al.
patent: 5155020 (1992-10-01), Paoletti et al.
patent: 5162333 (1992-11-01), Failli et al.
patent: 5175099 (1992-12-01), Wills
patent: 5202332 (1993-04-01), Hughes et al.
patent: 5204243 (1993-04-01), Paoletti et al.
patent: 5225336 (1993-07-01), Paoletti
patent: 5225539 (1993-07-01), Winter
patent: 5240846 (1993-08-01), Collins et al.
patent: 5260203 (1993-11-01), Ladner et al.
patent: 5278056 (1994-01-01), Bank et al.
patent: 5284656 (1994-02-01), Platz et al.
patent: 5304489 (1994-04-01), Rosen
patent: 5385908 (1995-01-01), Nelson et al.
patent: 5451569 (1995-09-01), Wong et al.
patent: 5484790 (1996-01-01), Failli et al.
patent: 5530006 (1996-06-01), Waranis et al.
patent: 5530101 (1996-06-01), Queen
patent: 5545806 (1996-08-01), Lonberg
patent: 5559112 (1996-09-01), Skotnicki et al.
patent: 5565332 (1996-10-01), Hoogenboom
patent: 5567709 (1996-10-01), Skotnicki et al.
patent: 5569825 (1996-10-01), Lonberg
patent: 5585089 (1996-12-01), Queen
patent: 5625126 (1997-04-01), Lonberg
patent: 5633425 (1997-05-01), Lonberg
patent: 5661016 (1997-08-01), Lonberg
patent: 5693761 (1997-12-01), Queen
patent: 5693762 (1997-12-01), Queen
patent: 5733743 (1998-03-01), Johnson
patent: 5736142 (1998-04-01), Sette
patent: 5741957 (1998-04-01), Deboer
patent: 5770429 (1998-06-01), Lonberg
patent: 5780462 (1998-07-01), Lee et al.
patent: 5789650 (1998-08-01), Lonberg
patent: 5814318 (1998-09-01), Lonberg
patent: 5837242 (1998-11-01), Holliger
patent: 5849992 (1998-12-01), Meade
patent: 5858657 (1999-01-01), Winter
patent: 5871907 (1999-02-01), Winter
patent: 5874299 (1999-02-01), Lonberg
patent: 5877218 (1999-03-01), Herzig
patent: 5877397 (1999-03-01), Lonberg
patent: 5989591 (1999-11-01), Nagi et al.
patent: 6015809 (2000-01-01), Zhu et al.
patent: 6468546 (2002-10-01), Mitcham et al.
patent: 6537968 (2003-03-01), Lezdey et al.
patent: 6891030 (2005-05-01), Chen
patent: 6962980 (2005-11-01), Mitcham et al.
patent: 7189563 (2007-03-01), Eaton et al.
patent: 7202334 (2007-04-01), Mitcham et al.
patent: 7304149 (2007-12-01), Murphy et al.
patent: 7622565 (2009-11-01), Chen
patent: 2002/0165347 (2002-11-01), Fox et al.
patent: 2002/0168762 (2002-11-01), Lieping et al.
patent: 2004/0175380 (2004-09-01), Allison et al.
patent: 2004/0229795 (2004-11-01), Roemisch et al.
patent: 2005/0163772 (2005-07-01), Dong et al.
patent: 2005/0202536 (2005-09-01), Chen et al.
patent: 2008/0159998 (2008-07-01), Ichim
patent: 2008/0160036 (2008-07-01), Chen
patent: 2008/0177039 (2008-07-01), Chen
patent: 2008/0206235 (2008-08-01), Chen
patent: 2009/0022747 (2009-01-01), Chen
patent: 2009/0087416 (2009-04-01), Chen
patent: 2009/0124573 (2009-05-01), Mazmanian
patent: 2009/0142342 (2009-06-01), Chen
patent: WO 90/07861 (1990-07-01), None
patent: WO 91/10741 (1991-07-01), None
patent: WO 91/17271 (1991-11-01), None
patent: WO 92/01047 (1992-01-01), None
patent: WO 92/20791 (1992-11-01), None
patent: WO 93/01222 (1993-01-01), None
patent: WO 95/04738 (1995-02-01), None
patent: WO 95/07707 (1995-03-01), None
patent: WO 95/16691 (1995-06-01), None
patent: WO 95/22972 (1995-08-01), None
patent: WO 97/17613 (1997-05-01), None
patent: WO 97/17614 (1997-05-01), None
patent: WO 98/23635 (1998-06-01), None
patent: WO 99/63088 (1999-12-01), None
patent: WO 00/01385 (2000-01-01), None
patent: WO 00/12758 (2000-03-01), None
patent: WO 00/36107 (2000-06-01), None
patent: 0202587 (2002-01-01), None
patent: 2004022594 (2004-03-01), None
patent: WO 2004/000221 (2004-12-01), None
patent: WO 2004/113500 (2004-12-01), None
patent: 2006101487 (2006-09-01), None
patent: 2006124667 (2006-11-01), None
patent: WO 2006/133396 (2006-12-01), None
patent: 2007039150 (2007-04-01), None
patent: 2007067681 (2007-06-01), None
patent: WO 2008/083239 (2008-07-01), None
patent: 2009089036 (2009-07-01), None
Huang, “Structural chemistry and therapeutic intervention of protein-protein interactions in immune response, human immunodeficiency virus entry, and apoptosis,”Pharmacology and Therapeutics, 86: 201-15 (2000).
Adachi, “Tumoricidal effect of human macrophage-colony-stimulating factor against human-ovarian-carcinoma-bearing athymic mice and its therapeutic effect when combined with cisplatin”,Cancer Immunol. Immunother.37(1): 1-6, (1993).
Aldovini, “Humoral and cell-mediated immune responses to live recombinant BCG-HIV vaccines”,Nature, 351:479-482 (1991).
Alexander, “Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides”,Immunity, 1(9):751-761 (1994).
Amoura, et al., “Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria”,Arthritis Rheum., 37(11):1684-8 (1994).
Bird, “Single-chain antigen-binding proteins”,Science, 242:423-426 (1988).
Bona, et al.,“Immnune Response : idiotype anti-idiotype network”,CRC Crit. Rev, Immunol., 1:33-81 (1981).
Bonder, et al., “Essential role for neutrophil recruitment to the liver in. concanavalin A-induced hepatitis”,J. Immunol., 172(1):45-53 (2004).
Bordignon, “Gene therapy in peripheral blood lymphocytes and-bone marrow for ADA-immunodeficient patients”,Science, 270:470-475 (1995).
Brown, et al., Treatment of mice with the neutrophil-depleting antibody RB6-8C5 results in early development of experimental lyme arthritis via the recruitment of Fr-I- polymorphonuclear leukocyte-like.
Cassatella, “The production of cytokines by polymorphonuclear neutrophils”,Immunol. Today, 16(1):21-6 (1995).
Chapman, “A phase I trial of intraperitoneal recombinant interleukin 2 in patients with ovarian carcinoma”,Investigational New Drugs, 6(3):179-188. (1988).
Chapoval et al., “Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules”,Methods Mol. Med.45:247-255(2000).
Chapoval, “Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules”,Mol. Biotechnol., 21:259-64 (2002).
Chapoval, et al., B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production,-Nat. Immunol., 2(3):269-74 (2001).
Chen, “Co-inhibitory molecules of the B7-CD28 family in the control of T-cell Immunity”,Nat. Rev. Immunol., 4(5):33647 (2004).
Chen, “Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter”,Hum. Mol. Genet., 12:2547-2558 (2003).
Chen, “Soluble TNF-alpha receptors ar
Ouspenski Ilia
Pabst Patent Group LLP
The Johns Hopkins University
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