Nerve growth factor antibody and process

Details Nerve growth factor antibody and process Nerve growth factor antibody and process

1978-05-23

1980-10-28

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 260112R, A61K 3900, C07G 700, A61K 3702

Patent

active

042306914

ABSTRACT:
An antibody is prepared from a stable new form of nerve growth factor having a molecular weight of about 116,000. The pure nerve growth factor is obtained from an extract of mouse submandibular gland or mouse saliva which is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The component rich in nerve growth factor is subjected to at least one additional chromatography step, usually two to four, to obtain pure nerve growth factor. The pure nerve growth factor then is injected into the blood system of an animal to form the antibody which is recovered from the animal's blood serum.

REFERENCES:
Chemical Abstracts, 82:53569s (1975), 70:36104w (1969), 82:166182d (1975), 85:141122h (1976).
Chemical Abstracts, 77:3631g (1972), 78:54510v (1973), 84:101113d (1976), 82:38835g (1975).

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