Human Ron-related gene variant associated with cancers

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S320100, C435S325000, C435S091400, C536S023100, C536S024330

Reexamination Certificate

active

07977470

ABSTRACT:
The invention relates to the nucleic acid and polypeptide sequences of three novel human Ron-related gene variants (Ron-V1, Ron-V2, and Ron-V3). The invention also provides a process for producing the polypeptides of the variants, as well as uses for the nucleic acid, polypeptide and antibodies to same in diagnosing human breast carcinoma, breast adenocarcinoma, cervix epidermoid carcinoma, cervix epitheloid carcinoma, colon adenocarcinoma, urinary bladder carcinoma, prostate carcinoma, esophagus epidermoid carcinoma and esophagus carcinoma.

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Maggiora, P., et al., Overexpression of the Ron gene in human breast carcinoma. Oncogene 16:2927-2933, (1998).
Peace, B.E., et al., Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancer. Cancer Res. 65:1285-93, (2005).
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Wang, M., et al., Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the Ron receptor tyrosine kinase. Carcinogenesis 24:1291-300, (2003).
Willet, C., et al., Human Ron receptor protein. Database EMBL, Accession No. AAW82791, Apr. 12, 1999.
Willett, C.G., et al., Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival. J Clin Invest. 99:2979-91, (1997).
Xu, X., et al., RNA-mediated gene splicing of the Ronreceptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells. Oncogene 23:8464-8474, (2004).
Zhou, Y., et al., Altered expression of the Ron receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing Ron variants and their oncogenic potential. Oncogene 22:186-197, (2003).

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