Peptide protein translation inhibitor and the use thereof...

Details Peptide protein translation inhibitor and the use thereof... Peptide protein translation inhibitor and the use thereof...

2011-01-04

2011-01-04

Audet, Maury (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C514S002600, C424S001690

Reexamination Certificate

active

07863413

ABSTRACT:
A peptide protein translation inhibitor has a size greater than 250 amino acids and it includes an amino acid sequence which is at least for 85% identical to an amino acid sequence SEQ ID No 1. It also relates to a fusion polypeptide which specifically inhibits an interesting target polynucleotide translation, in which the polypeptide includes the above defined inhibiting peptide fused with a RNA binding protein.

REFERENCES:
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patent: 2007/0083334 (2007-04-01), Mintz et al.
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Takahashi, Nobuhiro et al.: “Coexpression of the CUG-Binding Protein Reduces DM Protein Kinase Expression in COS Cells”, Journal of Biochemistry, vol. 130, No. 5, 2001, pp. 581-587, XP-002262154.
Good, Peter et al.: “A Family of Human RNA-binding Proteins Related to theDrosophilaBruno Translational Regulator”, Journal of Biological Chemistry, vol. 275, No. 37, Sep. 2000, pp. 28583-28592, XP-002262155.
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