Steroid derivatives and their use in radioimmunoassays

Details Steroid derivatives and their use in radioimmunoassays Steroid derivatives and their use in radioimmunoassays

1978-05-01

1980-10-28

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 1, 2603972, 2603974, 26039745, 2603975, C07J 900

Patent

active

042306213

ABSTRACT:
Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said derivative having a strong affinity for the antibodies of the steroid intended for radioimmunoassay; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4 and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays.

REFERENCES:
patent: 3925355 (1975-12-01), Piasio et al.
patent: 4021535 (1977-05-01), Polito
Smith et al., "Journ. Org. Chem.", vol. 26, (1961), pp. 3856-3858.

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