Method for enhancing leukocyte immune function

Details Method for enhancing leukocyte immune function Method for enhancing leukocyte immune function

2011-06-07

2011-06-07

Saucier, Sandra E. (Department: 1657)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S340000

Reexamination Certificate

active

07955847

ABSTRACT:
The present invention provides a method for enhancing the immune function of leukocytes in a subject, which comprises the steps of: (a) isolating leukocytes from the subject; (b) treating the leukocytes obtained from step (a) with an inhibitor of the endoplasmic reticulum calcium ion pump; and (c) administrating the treated leukocytes obtained from step (b) back to the subject. A pharmaceutical composition for enhancing the immune function of leukocytes in a subject and a method for preparing said pharmaceutical composition are also provided.

REFERENCES:
Hjalmar Lagast, P. Daniel Lew, and Francis A. Waldvogel “Adenosine Triphosphate-dependent Calcium Pump in the Plasma Membrane of Guinea Pig and Human Neutrophils” J. Clin. Invest. vol. 73, Jan. 1984, 107-115.
B. K. Rada et al. “Calcium signalling is altered in myeloid cells with a deficiency in NADPH oxidase activity” Clin Exp Immunol 2003;132:53-60.
Answers.com “Chronic Granulomatous Disease” Accessed Jun. 26, 2007.
Michael J. Chusid, M.D., and Peter A. Tomasulo, M.D. “Survival of Transfused Normal Granulocytes in a Patient With Chronic Granulomatous Disease” Pediatrics vol. 61 No. 4 Apr. 1978.
C. P. Engelfriet et al. “Granulocyte T ransfusions” Vox Sang 2000;79:59-66.
Roland Seifert, Rahel Burde and Giinter Schultz “Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides” Biochem. J. (1989) 259, 813-819.
Karolyn P. Shatwell, Anthony W. Segal “Molecules in Focus NADPH Oxidase” Int. J . Biochem. Cell Biol. vol. 28, No. 11, pp. 1191-1195, 1996.
Miklos Geiszt, Julia B. Szeberenyi, Krisztina Kaldi, and Erzsebet Ligeti “Role of Different Ca21 Sources in the Superoxide Production of Human Neutrophil Granulocytes” Free Radical Biology & Medicine, vol. 26, Nos. 9/10, pp. 1092-1099, 1999.
Rae, J., Newburger, P.E., Dinauer, M.C., Noack, D., Hopkins, P.J. and Curnutte, J.T. ; 1998. X-Linked chronic granulomatous disease: mutations on the CYBB gene encoding the gp91-phox component of respiratiory-burst oxidase.Am. J. Hum. Genet.62, 1320-1331.
Ellgaard, L., Molinari, M., and Helenius, A; 1999. Setting the standards: quality control in the secretory pathway.Science286, 1882-1888.
Heyworth, P.G., Curnutte, J.T., Noack, D. and Cross, A.R.; 1997. Hematologically important mutations: X-linked chronic granulomatous disease-an update.Blood Cells Mol. Dis.23, 443-450.
Roos, D., de-Boec-M., Kuribayashi. F. Meischl, C., Weeing, R.S., Segal, A.W., Ahlin, A., nemet, K., Hossle, J.P., Bernatowska-Matuszkiewicz, E. and Middleton-Price, H; 1996. Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease. [Revies][151 refs].Blood87, 1663-1681.
Lin, S.J., Huang, Y.F., Chen, J.Y., Heyworth, P.G., Noack, D., Wang, J.Y., Lin, C.Y., Chiang, B.L., Yang, C.M., Liu, C.C. and Shieh, C.C.; 2002. Molecular quality control machinery contributes to the leukocyte NADPH oxidase deficiency in chronic granulomatous disease.Biochim. Biophys. Acta1586, 275-286.
Yeghen, T. and Devereuxs S.; 2001. Granulocyte transfusion: review.Vox Sang.81, 87-92.
Yafang Huang and Chi-Chang Shieh; 2005. Rescuing mutant gp9lphox from ER to restore the NADPH oxidase function in X-CGD cells with thapsigargin.Experimental Biology 2005,San Diego Convention Center, CA, USA.

Affiliated with

Also associated with

Rating

Method for enhancing leukocyte immune function does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for enhancing leukocyte immune function, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for enhancing leukocyte immune function will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2669051