CSF3R polypeptides and uses thereof

Details CSF3R polypeptides and uses thereof CSF3R polypeptides and uses thereof

2011-01-18

2011-01-18

Landsman, Robert (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07871979

ABSTRACT:
The present invention relates to CSF3R polypeptide variants and their uses, particularly for therapeutic or prophylactic treatment in human subjects. The invention also relates to nucleic acids encoding said polypeptides, vectors comprising such nucleic acids and recombinant cells containing the same. The invention further discloses methods of producing such polypeptides, as well as methods and tools for detecting or dosing these polypeptides in any sample.

REFERENCES:
Ku et al., 1996, Blood, vol. 88, pp. 4124-4131 (see abstract).
Fukunaga, R. et al. “Three different mRNAs encoding human granulocyte colony-stimulating factor receptor”,Proc. Natl. Acad. Sci. USA, Nov. 1990, pp. 8702-8706, vol. 87, XP-002398193.
Seto, Y. et al. “Chromosomal Gene Organization of the Human Granulocyte Colony-Stimulating Factor Receptor”,Journal of Immunology, Jan. 1, 1992, pp. 259-266, vol. 148, No. 1, XP-002398198.
Hiraoka, O. et al. “Requirement for the Immunoglobulin-like Domain of Granulocyte Colony-stimulating Factor Receptor in Formation of a 2:1 Receptor-Ligand Complex”,Journal of Biological Chemistry, Oct. 27, 1995, pp. 25928-25934, vol. 270, No. 43, XP-002398196.
Barreda, D.R. et al. “Regulation of myeloid development and function by colony stimulating factors”,Development and Comparative Immunology, 2004, pp. 509-554, vol. 28, XP-002398199.
Rutella, S. et al. “Granulocyte Colony-Stimulating Factor: A Novel Mediator of T Cell Tolerance”,Journal of Immunology, 2005, pp. 7085-7091, vol. 175.
Iwasaki, H. et al. “Production of Soluble Granuloctye Colony-Stimulating Factor Receptors from Myelomonocytic Cells”,Journal of Immunology, 1999, pp. 6907-6911, vol. 163.
Asano, Y. et al. “Effect of the Chimeric Soluble Granulocyte Colony-Stimulating Factor Receptor on the Proliferation of Leukemic Blast Cells from Patients with Acute Myeloblastic Leukemia”,Cancer Res., Aug. 15, 1997, pp. 3395-3397, vol. 57, No. 16.
Druhan, L. J. et al. “Novel Mechanism of G-CSF Refractoriness in Patients with Severe Congenital Neutropenia”,Blood, 2005, pp. 584-591, vol. 105.
Database EMBL, Accession No. DB321299, “Homo sapienscDNA clone LIVER2004777, 3' end, mRNA sequence”, Oct. 25, 2003, XP-002398203, p. 1.
Database EMBL, Accession No. AY148100, “Homo sapienscolony stimulating factor 3 receptor (granulocyte) (CSF3R) gene, complete CDS”, Sep. 18, 2002, XP-002398204, pp. 1-14.
Layton, J. E. et al. “Identification of Ligand-binding Site III on the Immunoglobulin-like Domain of the Granulocyte Colony-stimulating Factor Receptor”,Journal of Biological Chemistry, Sep. 28, 2001, pp. 36779-36787, vol. 276, No. 39.

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