Spirocyclic cyclohexane compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S409000, C546S018000, C548S407000

Reexamination Certificate

active

07960404

ABSTRACT:
Spirocyclic cyclohexane compounds corresponding to formula Iin which R1and R2form a pyrrolidine ring or an azetidine ring and which exhibit increased metabolic stability, a process for producing such spirocyclic cyclohexane compounds, pharmaceutical compositions containing such spirocyclic cyclohexane compounds, and the use of such spirocyclic cyclohexane compounds to treat or inhibit pain and/or other disorders.

REFERENCES:
patent: 7332519 (2008-02-01), Hinze et al.
patent: 7547707 (2009-06-01), Hinze et al.
patent: 2005/0192333 (2005-09-01), Hinze et al.
patent: 2008/0125475 (2008-05-01), Linz et al.
patent: 2008/0221141 (2008-09-01), Friderichs et al.
patent: 2009/0163716 (2009-06-01), Hinze et al.
patent: 102 52 667 (2004-05-01), None
patent: 103 60 792 (2005-07-01), None
patent: 10 2005 016 460 (2006-10-01), None
patent: WO 2004/043967 (2004-06-01), None
patent: WO 2005/066183 (2005-07-01), None
patent: WO 2006/108565 (2006-10-01), None
Fuad A. Abdulla et al., “Axotomy Reduces the Effect of Analgesic Opioids Yet Increases the Effect of Nociceptin on Dorsal Root Ganglion Neurons”, The Journal of Neuroscience, Dec. 1, 1998, 18(23): 9685-9694.
Anthony L. Beck et al., “Synthesis of 3,4-Bridged Indoles by Photocyclisation Reactions. Part 2.1Photocyclisation of Halogenoacetyl Tryptophol Derivatives and α-Chloro Indol-3-ylalkanoate Esters”, J. Chem. Soc. Perkin Trans. 1, pp. 813-821, 1992.
Girolamo Calo et al., “Pharmacology of nociceptin and its receptor: a novel therapeutic target”, British Journal of Pharmacology (2000) 129, 1261-1283, Macmillan Publishers Ltd.
Simon J. Garden et al., “A versatile synthetic methodology for the synthesis of tryptophols”, Tetrahedron 58 (2002) 8399-8412, Pergamon.
Francois Jenck et al., “Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress”, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 14854-14858, Dec. 1997, Neurobiology.
I. Jirkovsky et al., “Synthesis of 1,3,4,9-Tetrahydro-1-alkylthiopyrano [3,4-b] indole-1-acetic Acids. The Sulfur Isoster of Prodolic Acid”, vol. 12, pp. 937-940, Ayerst Research Laboratories, Montreal, Quebec, Canada, Oct. 1975.
Michael A. King et al., “Spinal analgesic activity of orphanin FQ
ociceptin and its fragments”, Neuroscience Letters 223 (1997) 113-116, Elsevier Science Letters.
Daniel Lednicer et al., “4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring”, The Upjohn Company, Research Laboratories, Kalamazoo, Michigan.
Toshiya Manabe et al., “Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors”, Letters to Nature, vol. 394, pp. 577- 581, Aug. 6, 1998, Macmillan Publishers Ltd.
Jean-Claude Meunier et al., “Isolation and structure of the endogenous agonist of opioid receptor-like ORL1receptor” Letters of Nature, vol. 377, pp. 532-535, Oct. 12, 1995.
J. S. Mogil et al., “Orphanin FQ is a Functional Anti-Opioid Peptide”, Letter to Neuroscience, Neuroscience vol. 75, No. 2, pp. 333-337, 1996, Elsevier Science Ltd., Pergamon, Great Britain.
Miyuki Nishi et al., “Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor”, The EMBO Journal, vol. 16, No. 8, pp. 1858-1864, 1997, Oxford University Press.
Rainer K. Reinscheid et al., “Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor”, Science, vol. 270, pp. 792-794, Nov. 3, 1995.
Van Bac et al., “New Strategy in the Stereocontrolled Synthesis of the Spiro Ketal Subunit of Milbemycins”, Tetrahedron Letters, vol. 29, No. 23, pp. 2819-2822, 1988, Pergamon Press plc, Great Britain.
Marco Bandini et al., “InBr3-Catalyzed Friedel-Crafts Addition of Indoles to Chiral Aromatic Epoxides: A Facile Route to Enantiopure Indolyl Derivatives”, JOC Note, J. Org. Chem. 2002, 67, 5386-5389.
Peter D. Davis et al., “Inhibitors of Protein Kinase C. 1.12,3-Bisarylmaleimides”, J. Med. Chem. 1992, 35, 177-184.
D. Mark Gleave et al., “Synthesis and Antibacterial Activity of [6,5,5] and [6,6,5] Tricyclic Fused Oxazolidinones”, Bioorganic & Medicinal Chemistry Letters 8 (1998) 1231-1236.
Katsuya Kato et al., “Synthesis of α-trifluoromethylated indoleacetic acid: a potential peroxidase-stable plant growth regulator”, Journal of Fluorine Chemistry 99 (1999) 5-7.
Alan R. Katritzky et al., “The Chemistry of N-Substituted Benzotriazoles; Part 11. 1 The Preparation of Tertiary Amines Containing Tertiary-Alkyl Groups from Ketones, Secondary Amines, and Organometallic Reagants”, Communications, Synthesis, pp. 66-69, Jan. 1989.
Alan H. Katz et al., “Synthesis and Analgesic Activity of Pemedolac (cis-1-Ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl) pyrano[3,4-b]indole-1-acetic Acid)”, J. Med. Chem. 1988, 31, 1244-1250.
Chunrong Ma et al., “Efficient Asymmetric Synthesis of Biologically Important Tryptophan Analogues via a Palladium-Mediated Heteroannulation Reaction”, J. Org. Chem. 2001, 66, 4525-4542.
T. Sandmeyer, “Ueber Isonitrosoacetanilide and deren Kondensation zu Isatinen”, The British Library, pp. 234-242, 1919.
Masafumi Yamagishi et al., “Biological Activities and Quantitative Structure-Activity Relationships of Spiro[imidazolidine-4,4′(V′H)-quinazoline]-2,2′,5(3′H)-triones as Aldose Reductase Inhibitors”, J. Med. Chem. 1992, 35, 2085-2094.
Tetsuro Shinada et al., “Facile Synthesis of 6-Hydroxyindole-3-acetic Acid: On the Structure of the Aromatic Subunit of Nephilatoxin-1˜6”, Tetrahedron Letters, vol. 37, No. 39, pp. 7099-7102, 1996, Great Britain.
Aeri Park et al., “New solid-state chemistry technologies to bring better drugs to market: knowledge-based decision making”, Expert Opin. Drug Discov. (2007) 2(1), pp. 145-154.
Ali Ardati et al., “Interaction of [3H] Orphanin FQ and125I-Tyr14-Orphanin FQ with the Orphanin FQ Receptor: Kinetics and Modulation by Cations and Guanine Nucleotides”, Molecular Pharmacology, vol. 51, pp. 816-824 (1997).
German Search Report dated Aug. 28, 2007 w/partial English translation (nine (9) pages).
International Search Report dated Jul. 15, 2008 w/partial English translation (four (4) pages).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Spirocyclic cyclohexane compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Spirocyclic cyclohexane compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spirocyclic cyclohexane compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2660788

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.