Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2011-07-19
2011-07-19
Souw, Bernard E (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S281000, C250S283000, C702S022000, C702S023000, C702S026000, C702S027000, C702S028000
Reexamination Certificate
active
07982181
ABSTRACT:
A method of analyzing data from a mass spectrometer provides data-dependent acquisition. An extracted ion chromatogram (XIC) is created for each m/z data point of mass spectral scans and the XIC for each m/z data point are correlated to a model function to obtain a XIC correlation value. A weighting function is applied to the XIC correlation value to obtain a current weighted intensity for each m/z point, which is used to reconstruct a weighted mass spectrum. The value or range of intensities of interest of the weighted intensity data or raw data is transformed from the time domain into the frequency domain, and the transformed data is used to make a real-time decision for the data-dependent acquisition. The data-dependent acquisition can be the performance of tandem mass spectrometry. A sample processing apparatus receives the sample and a computer readable medium provides instructions to the apparatus.
REFERENCES:
patent: 4682027 (1987-07-01), Wells
patent: 4941101 (1990-07-01), Crilly
patent: 5107109 (1992-04-01), Stafford, Jr. et al.
patent: 5436447 (1995-07-01), Shew
patent: 5481476 (1996-01-01), Windig
patent: 5572022 (1996-11-01), Schwartz et al.
patent: 5672869 (1997-09-01), Windig et al.
patent: 5885841 (1999-03-01), Higgs et al.
patent: 6002986 (1999-12-01), Mito
patent: 7009174 (2006-03-01), Le Blanc
patent: 7223965 (2007-05-01), Davis
patent: 7279679 (2007-10-01), Old et al.
patent: 7297941 (2007-11-01), Senko et al.
patent: 7501621 (2009-03-01), Willis et al.
patent: 7519488 (2009-04-01), Fu et al.
patent: 2004/0181351 (2004-09-01), Thompson et al.
patent: 2004/0191351 (2004-09-01), Kim et al.
patent: 2004/0195500 (2004-10-01), Sachs et al.
patent: 2004/0251409 (2004-12-01), Le Blanc
patent: 2005/0016276 (2005-01-01), Guan et al.
patent: 2005/0261838 (2005-11-01), Andreev et al.
patent: 2005/0288872 (2005-12-01), Old et al.
patent: 2006/0243900 (2006-11-01), Overney et al.
patent: 2006/0255258 (2006-11-01), Wang et al.
patent: 2006/0284067 (2006-12-01), Senko et al.
patent: 2006/0284069 (2006-12-01), Le Blanc
patent: 2007/0023633 (2007-02-01), Wang et al.
patent: 2008/0067346 (2008-03-01), Amster et al.
patent: 2008/0149821 (2008-06-01), Senko
Andreev et al., “A Universal Denoising and Peak Picking Algorithm for LC-MS Based on Matched Filtration in the Chromatographic Time Domain,” Anal. Chem., vol. 75 (No. 22), p. 6314-6326, (2003).
Kohli et al., “An Alternative Sampling Algorithm for Use in Liquid Chromatography/Tandem Mass Spectrometry Experiments,” Rapid Commun. Mass Spectrom, Wiley InterScience, p. 589-596, (2005).
Wenner et al, “Factors that Affect Ion Trap Data-Dependent MS/MS in Proteomics,” J Am Soc Mass Spectrom, vol. 15, p. 150-157, (2004).
Logie Michael J
Souw Bernard E
Staggs Michael C.
Thermo Finnigan LLC
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