Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-07-26
2011-07-26
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C435S007100
Reexamination Certificate
active
07985561
ABSTRACT:
The present invention provides, for the first time, the finding that the manganese superoxide dismutase Val16Ala polymorphism is significantly associated with prognosis for cancer patients treated with chemotherapeutic drug therapy. The alanine allele is a novel biomarker that predicts poor response and poor outcome to chemotherapeutic drug cancer therapy. Conversely, the valine allele predicts a good response and a good outcome to chemotherapeutic drug cancer therapy. Therefore, a genotype assay can be used to determine which alleles a subject is carrying, and subsequently this information can be used to determine if chemotherapeutic drug therapy is appropriate, and to customize therapy according to the patient's MnSOD genotype.
REFERENCES:
patent: WO 01//75175 (2001-10-01), None
patent: WO 2006/012361 (2006-02-01), None
Slaughter et al, PNAS, 1981, 78:1124-1128.
Campbell, General Properties and Applications of Monoclonal Antibodies, pp. 1-32, in Monoclonal Antibody Technology, 1984, Elsevier Science Publishers.
Bergman et al, J Cancer Res Clin Oncol, 2005, 131:439-444.
Wang et al, Eur J Canver, 2009, 45:2874-2881.
Busken, C et al, Digestive Disease Week Abstracts and Itinerary Planner, 2003, abstract No: 850.
Krontiris and Capizzi, Internal Medicine, 4th Edition, Editor-in-chief Jay Stein, Elsevier Science, 1994 Chapters 71-72, pp. 699-729.
Tockman et al, Cancer Res., 1992, 52:2711s-2718s.
Kaiser, Science, 2006, 313, 1370.
Ambrosone et al., “Manganese Superoxide Dismutase (MnSOD) polymorphism and breast cancer in a population-based case-control study,” 1999, Cancer Research, 59, 602-606.
Ambrosone et al., “Polymorphisms in Genes Related to Oxidative Stress (MPO, MnSOD, CAT) and Survival After Treatment for Breast Cancer,” 2005, Cancer Res., 65, 3, 1105-1111.
Beck et al., “Human Mn superoxide dismutase cDNA sequence,” 1987, Nucleic Acid Research, vol. 15, No. 21, 9076.
Bergman et al., “Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women,” 2005, J. Cancer Res. Clin. Oncol., 131(7), 439-444.
Egan et al., “MnSOD polymorphism and breast cancer in a population-based case-control study,” 2003, Cancer Lett., 199(1): 27-33.
Green et al., “Variation in the manganese superoxide dismutase gene (SOD2) is not a major cause of radiotherapy complications in breast cancer patients,” 2002, Radiotherapy and Oncology, 63, 213-216.
Hecki, “Isolation of cDNAs encoding human manganese superoxide dismutase,” 1988, Nucleic Acids Research, vol. 16, No. 13, 6224.
Hiroi et al.,“Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese,” 1999, Biochem Biophys Res. Commun., 261(2), 332-339.
Hur et al., “Manganese Superoxide Dismutase Expression Correlates with Chemosensitivity in Human Gastric Cancer Cell Lines,” 2003, vol. 9, 5768-5775.
International Preliminary Report dated Nov. 20, 2008, received in related International Application No. PCT/US2007/068588, filed May 9, 2007.
International Search Report dated Apr. 12, 2007, received in related International Application No. PCT/US2007/068588, filed May 9, 2007.
Kamatani et al., “Polymorphic mutations of the Mn-SOD gene in intact human lymphocytes and oral squamous cell carcinoma cell lines,” 2003, Biochem. Cell Biol., 81(1), 43-50.
Martin et al., “No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1).,” 2005, J. Surg. Res., 124(1), 92-97.
Mitrunen et al., “Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk,” 2001, Carcinogenesis, vol. 22, No. 5, pp. 827-829.
Rosenblum et al., “On signal sequence polymorphisms and diseases of distribution,” 1996, Proc. Natl. Acad. Sci. , vol. 93, pp. 4471-4473.
Stoehlmacher et al., “The -9Ala/-9Val polymorphism in the mitochondrial targeting sequence of the manganese superoxide dismutase gene (MnSOD) is associated with age among Hispanics with colorectal carcinoma,” 2002, Oncol. Rep., 9(2), 235-238.
Suresh et al., “Overexpression of manganese superoxide,” 2003, British Journal of Haematology, 120, 457-463.
Sutton et al., “The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria,” 2003, Pharmacogenetics, 13(3), 145-157.
Sutton et al., “The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability,” 2005, Pharmacogenet Genomics, 15(5), 311-319.
Tamimi et al., “Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer,” 2004, Cancer Epidemiol Biomarkers Prev., 13(6), 989-996.
Valenti et al., “The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis,” 2004, J. Med. Genet., 41, 946-950.
Wang et al., “Asbestos exposure, manganese superoxide dismutase (MnSOD) genotype, and lung cancer risk,” 2004, J. Occup. Environ. Med., 46(6), 556-564.
Written Opinion dated Nov. 20, 2008, received in related International Application No. PCT/US2007/068588, filed May 9, 2007.
Yen, et al., “The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice,” 1996, J. Clin. Invest., vol. 98, No. 5, 1253-1260.
Ambs Stefan
Boersma Brenda
Halvorson Mark
Kilpatrick Townsend & Stockton LLP
The United States of America as represented by the Department of
Yu Misook
LandOfFree
Manganese superoxide dismutase Val16Ala polymorphism... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Manganese superoxide dismutase Val16Ala polymorphism..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Manganese superoxide dismutase Val16Ala polymorphism... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2656501