Bone tropic peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07871978

ABSTRACT:
The present invention is directed to the use of bone tropic peptides identified through the use of a phage display library. More particularly, the invention is directed to compositions comprising the bone tropic peptides and methods for using such compositions to regulate osteogenesis, cell adhesion and angiogenesis, and diseases and disorders thereof, and to inhibit cancer cell metastasis and growth.

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Christian et al. Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels. JCB, Nov. 24, 2003, pp. 871-878.
Sporn et al. Chemoprevention of cancer. Carcinogenesis. 2000. vol. 21, No. 3, pp. 525-530.
Bab et al. Histone H4-related osteogenic growth peptide (OGP): a novel circulating stimulator of osteoblastic activity. The EMBO Journal. 1992. vol. 11, Nol. 5, pp. 1867-1873.

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