Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2011-08-30
2011-08-30
Wang, Shengjun (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S634000
Reexamination Certificate
active
08008353
ABSTRACT:
Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
REFERENCES:
patent: 4201788 (1980-05-01), Voorhees et al.
patent: 4847257 (1989-07-01), Hupe et al.
patent: 5037846 (1991-08-01), Saccomano et al.
patent: 5091576 (1992-02-01), Bergeron
patent: 5242947 (1993-09-01), Cherksey et al.
patent: 5460807 (1995-10-01), Cardin et al.
patent: 5498522 (1996-03-01), Porter et al.
patent: 5516807 (1996-05-01), Hupe et al.
patent: 5541230 (1996-07-01), Basu et al.
patent: 5580715 (1996-12-01), McGrath et al.
patent: 5639600 (1997-06-01), McGrath et al.
patent: 5665588 (1997-09-01), Kornbluth
patent: 5672746 (1997-09-01), Nau et al.
patent: 5677350 (1997-10-01), Frydman
patent: 5679682 (1997-10-01), Bergeron
patent: 5880161 (1999-03-01), Basu et al.
patent: 5886051 (1999-03-01), Bergeron, Jr. et al.
patent: 5889061 (1999-03-01), Frydman et al.
patent: 6392098 (2002-05-01), Frydman et al.
patent: 0 162 413 (1985-11-01), None
patent: 0 277 635 (1988-08-01), None
patent: 0 399 519 (1990-11-01), None
patent: 0 415 801 (1991-03-01), None
patent: 0 415 801 (1991-03-01), None
patent: 0 436 332 (1991-07-01), None
patent: 60-6348 (1985-02-01), None
patent: 08217670 (1996-08-01), None
patent: WO 92 13548 (1992-08-01), None
patent: WO 93 04036 (1993-03-01), None
patent: WO 93 14782 (1993-08-01), None
patent: WO 96 04019 (1996-02-01), None
patent: WO 97/33175 (1997-12-01), None
patent: WO 98 17624 (1998-04-01), None
patent: WO 99 03823 (1999-01-01), None
Rizzo et al. “Pharmacokinetic profile of mitoguazone (MGBG) in patient with AIDS related non-Hodgkin's lymphoma,” Investigational New Drugs, 1996, vol. 14, pp. 227-234.
Von Hoff “MGBG: Teaching an old drug new tricks,” Annals of Oncology, 1994, vol. 5, pp. 487-493.
Basu et al. “The Ability of Polyamine Analogues to Induce Z-DNA Structure in Synthetic Ploynucleotides in Vitro in Inversely Correlates with their Effects on Cytotoxcity of Cisdiaminedichloroplatinum (II) (CDDP) in Human Brain Tumor Cell Lines” (1996) Anticancer Res. 16:39-48.
Bellevue , III et al. “Structural Comparison of Alkylpolyamine Analogues with Potent in Vitro Antitumor or Antiparasitic Activity” (1996) Bioorg. Med. Chem. Lett. 6:2765-2770.
Bergeron et al. “Two Polyamine Analogs (BE-4-4-4 and BE-4-4-4-4) Directly Affect Growth, Survival, and Cell Cycle Progression in Two Human Brain Tumor Cell Lines” (1995) Cancer Chemother. Pharmacol. 36:411-417.
Bersnstein et al. “The Cellular Localization of the L-Orinthine Decarboxylase Polyamine System in Normal and Diseased Central Nervous Systems,” Progress in Neurobiology 57(5):485-505, 1999.
Bitonti et al. “Bis(benzyl)poluamine Analogs Inhibit the Growth of Chloroquine-Resistant Human Malaria Parasites (Plasmodium falciparum) In Vitro and In Combination With α-Difluoromethylomithine Cure Murine Malaria” (1989) Proc. Natl. Acad. Sci. USA 86:651-655.
Chiang et al. “Antihuman Immunodeficiency Virus (HIV-1) Activities of Inhibitors of Polyamine Pathways,” J. Biomed. Sci. 3(2): 78-81, 1996.
Fields et al., “Fields Virology,” vol. 2, 1996, Lippincott Williams & Wilkins, pp. 2418-2419.
Fogel-Petrovic et al. “Effects of Polyamines, Polyamine Analogs, and Inhibitors of Protein Synthesis on Spermidine-Spermine N′-Acetyltransferase Gene Expression,” (1996) Biochemistry 35:14436-14444.
Gabrielian et al., “Effect of Leukopenia on Experimental Post-Traumatic Retinal Detachment” (1993) Curr. Eye Res. 13:1-9.
Greene et al., Protective Groups in Organic Synthesis, 2ndEd., John Wiley & Sons, Inc. New York. (Table of Contents) (1991).
Hibasami et al., “Antitumor Effect of a New Multienzyme Inhibitor of Polyamine Synthetic Pathway, Methyglyocal-Bis(Cyclopentylamidinohydrazone), Against Human and Mouse Leukemia Cells” (1989) Cancer Res. 49:2065-2068.
Kackzmarek et al., “Inhibitors of Polyamine Biosynthesis Block Tumor Necrosis Factor-Induced Activation of Macrophages,” Cancer Res. 52(7):1891-1894, 1992.
Kramer et al., “Use of 4-Fluoro-l-ornithine to Monitor Metabolic Flex Through The Polyamine Biosynthetic Pathway” (1995) Biochem. Pharmacol. 50:1433-1443.
Lim et al., “MGBG Therapy of Relasped Extralymphatic HIV-Associated Non-Hodgkins Lymphoma (HIV NHL),” (Mar. 14, 1995) Proc. Annu. Meet. Am. Soc. Clin. Oncol. 14:A1274.
Marton et al., “Polyamines As Targets for Therapeutic Intervention” (1995) Ann Rev. Pharmacol. Toxicol. 35:55-91.
Mascolini. “Oncologists Scout New Direction for KS and Lymphoma Therapies,” (1995) J. Int. Assoc. Physicians Aids Care 1(5):10-14.
McGrath et al., “Indentification of A Clonal Form Of HIV In Early Kaposi's Sarcoma: Evidence For A Novel Model Of Oncogenesis, ‘Sequential Neoplasia’”(1995) J. Acquired Inn. Def. Syn. Hum. Retro. 8:379-385.
Messina et al., “Polyamine Involvement In Functional Activation of Human Macrophages,” (1992) J. Leukoc. Biol. 52(6):585-587.
Miles et al., “Curative Therapy of AIDS Cancers,” (Jul. 1, 1996) Int. Conf. AIDS. XI(1):28.
Mukhopadhyay et al., “Effects of Bis(Benzl)Polyamine Analogs On Leishmania Donavani Promatigotes,” (1995)Exper. Parasitology 81:39-46.
Pennings et al., “Sensitization of TNF-Induced Apoptosis With Polyamine Synthesis Inhibitors in Difference Human and Murine Tumor Cell Lines,”Cytokine 10(6):423-431, 1998.
Porter et al., “Polyamine Inhibitors and Analogues As Potential Anticancer Agents,” (1992) Falk Symposium 62-Polyamines In The Gastrointestinal Tract Chapter 31, pp. 301-322, 1992.
Prakash et al., “Antitumor Activity of Norspemidine, A Structural Homologue of the Natural Polyamine Spermindine,” Anticancer Research 8:563-568 (1998).
Pulliam et al., “Unique Monocyte Subset in Patients with AIDS Dementia,” (1997) Lancet 349:692-695.
Reminton's Pharmaceutical Sciences, 18thEdition, Mack Publishing (1990) (Table of Contents).
Rizzo et al., “Pharmacokinetic Profile of Mitoguazone (MGBG) In Patients With AIDS Related Non-Hodgkins Llymphoma,” (1996), Inventigational New Drug, vol. 14, pp. 227-234.
Shiramizu et al., “Identification of a Common Clonal Human Immunodeficiency Virus Integration Site in Human Immunodeficiency Virus-Associated Lymphomas”, (1994) Cancer Res. 54:2069-2072.
Von Hoff, “MGBG: Teaching an Old Drug New Tricks,” (1994), Annals of Oncology, vol. 5. pages 487-493.
Wojewodzka et al., “Structure-Activity Relationship of Polyamine Derivatives of 1, 3-Dichloracetone-Thiosemicarbazone: Induction of Metastases and Increase In Sialylation of Murine Lymphoma L5178Y-R Cells,” Chem. Biol. Interactions, 74 (1990) 221-223.
Bozicevic Field & Francis LLP
Francis Carol L.
The Regents of the University of California
Wang Shengjun
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