Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-05-03
2011-05-03
Saeed, Kamal A (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07935824
ABSTRACT:
The invention relates a compound represented by the formula (1):in-line-formulae description="In-line Formulae" end="lead"?Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4 (1)in-line-formulae description="In-line Formulae" end="tail"?wherein R1and R2represent H or the like; Q1represents an aromatic ring, heterocyclic ring or the like; Q2represents a single bond, aromatic ring, heterocyclic ring or the like; Q3represents a groupor the like, Q4represents an aromatic ring, heterocyclic ring or the like; and T1represents —CO— or —SO2—, and a medicine which comprises the compound and is useful for thrombosis and embolism.
REFERENCES:
patent: 5430150 (1995-07-01), Trova et al.
patent: 5668159 (1997-09-01), Jin et al.
patent: 5707994 (1998-01-01), Ikeda et al.
patent: 5811441 (1998-09-01), Olson et al.
patent: 5849736 (1998-12-01), Wityak et al.
patent: 5852045 (1998-12-01), Askew et al.
patent: 6300330 (2001-10-01), Stocker et al.
patent: 6359134 (2002-03-01), Tawada et al.
patent: 6525042 (2003-02-01), Kobayashi et al.
patent: 6642264 (2003-11-01), Hayashibe et al.
patent: 6747023 (2004-06-01), Kobayashi et al.
patent: 7192968 (2007-03-01), Yoshino et al.
patent: 7342014 (2008-03-01), Ohta et al.
patent: 7365205 (2008-04-01), Ohta et al.
patent: 2005/0245565 (2005-11-01), Ohta et al.
patent: 2006/0004009 (2006-01-01), Yoshino et al.
patent: 2006/0252837 (2006-11-01), Ohta et al.
patent: 2007/0129371 (2007-06-01), Nakamoto et al.
patent: 2008/0015215 (2008-01-01), Ohta et al.
patent: 2010/0099660 (2010-04-01), Ohta et al.
patent: 0 937 711 (1999-08-01), None
patent: 0 937 723 (1999-08-01), None
patent: 1 102 766 (2001-05-01), None
patent: 06-174919 (1994-06-01), None
patent: 2000-86659 (2000-03-01), None
patent: 2000-302765 (2000-10-01), None
patent: 2001-11071 (2001-01-01), None
patent: WO 93/10022 (1993-05-01), None
patent: WO 93/16038 (1993-08-01), None
patent: WO 94/20062 (1994-09-01), None
patent: WO 94/21599 (1994-09-01), None
patent: WO 95/11228 (1995-04-01), None
patent: WO 95/18111 (1995-07-01), None
patent: WO 96/10022 (1996-04-01), None
patent: WO 96/26187 (1996-08-01), None
patent: WO 96/31501 (1996-10-01), None
patent: WO 96/37482 (1996-11-01), None
patent: WO 96/38426 (1996-12-01), None
patent: WO 96/40100 (1996-12-01), None
patent: WO 97/14417 (1997-04-01), None
patent: WO 97/29104 (1997-10-01), None
patent: WO 97/38984 (1997-10-01), None
patent: WO 97/48395 (1997-12-01), None
patent: WO 98/06705 (1998-02-01), None
patent: WO 98/06707 (1998-02-01), None
patent: WO 98/15262 (1998-04-01), None
patent: WO 98/21188 (1998-05-01), None
patent: WO 98/35956 (1998-08-01), None
patent: WO 98/45262 (1998-10-01), None
patent: WO 98/46599 (1998-10-01), None
patent: WO 98/54164 (1998-12-01), None
patent: WO 98/57931 (1998-12-01), None
patent: WO 98/57931 (1998-12-01), None
patent: WO 98/57952 (1998-12-01), None
patent: WO 99/00121 (1999-01-01), None
patent: WO 99/00126 (1999-01-01), None
patent: WO 99/00127 (1999-01-01), None
patent: WO 99/06371 (1999-02-01), None
patent: WO 99/09027 (1999-02-01), None
patent: WO 99/16747 (1999-04-01), None
patent: WO 99/20606 (1999-04-01), None
patent: WO 99/45939 (1999-09-01), None
patent: WO 00/59913 (1999-10-01), None
patent: WO 99/57099 (1999-11-01), None
patent: WO 99/57112 (1999-11-01), None
patent: WO 99/57113 (1999-11-01), None
patent: WO 00/04001 (2000-01-01), None
patent: WO 00/06570 (2000-02-01), None
patent: WO 00/09480 (2000-02-01), None
patent: WO 00/35900 (2000-06-01), None
patent: WO 00/39111 (2000-07-01), None
patent: WO 00/39117 (2000-07-01), None
patent: WO 00/39118 (2000-07-01), None
patent: WO 00/47573 (2000-08-01), None
patent: WO 00/53264 (2000-09-01), None
patent: WO 00/39092 (2000-10-01), None
patent: WO 00/71516 (2000-11-01), None
patent: WO 00/76971 (2000-12-01), None
patent: WO 00/78749 (2000-12-01), None
patent: WO 01/17990 (2001-03-01), None
patent: WO 01/19788 (2001-03-01), None
patent: WO 01/19795 (2001-03-01), None
patent: WO 01/19798 (2001-03-01), None
patent: WO 01/27090 (2001-04-01), None
patent: WO 01/38309 (2001-05-01), None
patent: WO 01/64642 (2001-09-01), None
patent: WO 01/64643 (2001-10-01), None
patent: WO 02/02519 (2002-01-01), None
patent: WO 03/000657 (2002-03-01), None
patent: WO 02/26712 (2002-04-01), None
patent: WO 02/26720 (2002-04-01), None
patent: WO 02/26734 (2002-04-01), None
patent: WO 02/42270 (2002-05-01), None
patent: WO 03/000680 (2002-06-01), None
patent: WO 02/060859 (2002-08-01), None
patent: WO 03/016302 (2002-08-01), None
patent: WO 02079145 (2002-10-01), None
patent: WO 02/102380 (2002-12-01), None
patent: WO 03/045912 (2003-06-01), None
patent: WO 03/048158 (2003-06-01), None
patent: WO 03/026652 (2003-10-01), None
patent: WO 03/048081 (2003-10-01), None
Torneiro, M., et al., “Simple Synthetic Receptors that Bind Peptides in Water,” Tetrahedron, 53, No. 26,1997, pp. 8739-8750.
Abstracts of Papers, Part 1, 218thACS National Meeting, 0-8412-3685-2, Medi 29 and Medi 199, 3 pages, Aug. 22-26,1999.
Abstracts of Papers, Part 2, 219thACS National Meeting, 0-8412-3731-X, Medi 187, 2 pages, Mar. 26-30, 2000.
Abstracts of Papers, Part 1, 220thACS National Meeting, 0-8412-3749-2, Medi 289 and Medi 328, 3 pages, DC Aug. 20-24, 2000.
Abstracts of Papers, Part 2, 221stACS National Meeting, 0-8412-3788-3, Medi 128 (with poster), 3 pages, Apr. 1-5, 2001.
Abstracts of Papers, Part 2,226thACS National Meeting, 0-8412-3889-8, Medi 79 (with poster), 3 pages, Sep. 7-11, 2003.
Chemical Abstracts, vol. 129, Abstract No. 275469RN=213460-06-1, etc., J. Org. Chem., 63, No. 20, pp. 6762-6763, 1998.
Tetrahedron Letters, 39, No. 13, pp. 1713-1716, RN=205495-66-6, 1998.
J. Am. Chem. Soc., vol. 119, No. 6, pp. 1484-1485, RN=187458-11-3, 1997.
Tetrahedron Letters, vol. 37, No. 45, pp. 8165-8168, RN=183891-95-4, 183-97-6, 1996.
J. Chromatogr., A, vol. 724, No. 1-2, pp. 79-90, RN=16191-60-6, Jun. 24, 1994.
J. Med. Chem., vol. 36, No. 23, pp. 3526-3532, RN=151227-27-9,151226-77-6, 1993.
J. Med. Chem., vol. 18, No. 11, pp. 1088-1094, RN=57154-72-0, 1975.
S. M. Sheehan, et al., Bioorganic & Medicinal Chemistry Letters, vol. 13, pp. 2255-2259, “A Four Component Coupling Strategy for the Synthesis of D-Phenylglycinamide-Derived Non-Covalent Factor Xa Medi 289INHIBITORS”, 2003.
Y. K. Yee, et al., J. Med. Chem., vol. 43, No. 5, pp. 873-882, “N2-Aroylanthranilamide Inhibitores of Human Factor Xa”, 2000.
D. K. Herron, et al., J. Med. Chem., vol. 43, No. 5, pp. 859-872. “1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa”, 2000.
C. Wu, et al., Bioorganic &Medicinal Chemistry, vol. 5, No. 10, pp. 1925-1934, “Stereochemical Influence on the Stability of Radio-Metal Complexes in Vivo. Synthesis and Evaluation of the Four Stereoisomers of 2-(p-Nitrobenzyl)-Trans-CyDTPA”, 1997.
Y.-L. Chou, et al., Bioorganic & Medicinal Chemistry Letters, vol. 13, pp. 507-511, “Structure-Activity Relationships of Substituted Benzothiophene-Anthranilamide Factor Xa Inhibitors”, 2003.
M. Adler, et al., Biochemistry, vol. 41, No. 52, pp. 15514-15523, “Crystal Structures of Two Potent Nonamidine Inhibitors Bound to Factor Xa”, 2000.
J. J. Masters, et al., J. Med. Chem., vol. 43, No. 11, pp. 2087-2092, “Non-Amidine-Containing 1,2-Dibenzam1dobenzene Inhibitors of Human Factor Xa With Potent Anticoagulant and Antithrombotic Activity”, 2000.
M. R. Wiley, et al., J. Med. Chem., vol. 43, No. 5, pp. 883-899, “Structure-Based Design of Potent, Amidinederived Inhibitors of Factor Xa: Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity”, 2000.
U.S. Appl. No. 12/259,496, filed Oct. 28, 2008, Ohta, et al.
U.S. Appl. No. 12/250,586, filed Oct. 14, 2008, Ohta, et al.
H. Kawakubo, et al., “(R)-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridines: Novel Optically Active Compounds with Strong 5-HT1AReceptor Binding Ability Exhibiting Anticonflict Activity and Lessening of Memory Impairment”, Journal of Medicinal Chemistry, 1993, vol. 36, pp. 3526-3
Haginoya Noriyasu
Kanno Hideyuki
Nagamochi Masatoshi
Nagata Tsutomu
Yoshikawa Kenji
Bianchi Kristin
Daiichi Pharmaceutical Co. Ltd.
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
Saeed Kamal A
LandOfFree
Ethylenediamine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ethylenediamine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ethylenediamine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2646033