Method for measuring human megalin

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007200, C436S518000

Reexamination Certificate

active

07955809

ABSTRACT:
This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are specific to cells, tissues, or organs, in a site-directed manner at an early stage. Measurement of human megalin enables detection of a disease in an organ in which megalin expression is observed.

REFERENCES:
patent: 2004/0204357 (2004-10-01), Brautigam et al.
patent: 2004/0235161 (2004-11-01), Tabata et al.
patent: 4-351962 (1992-12-01), None
patent: 8-105889 (1996-04-01), None
patent: WO 03/102493 (2003-12-01), None
Jordan (The Protein Protocol Handbook, second edition, edited by Walker, year 2000, p. 1083-1088).
Willnow et al. (PNAS 1996 vol. 93 p. 8460-8464).
Marion De Jong PhD et al., “Megalin Is Essential for Renal Proximal Tubule Reabsorption of111In-DTPA-Octreotide”, The Journal of Nuclear Medicine, vol. 46, No. 10, Oct. 2005, pp. 1696-1700.
Supplementary European Search Report EP 07 74 0098 dated Aug. 24, 2009.
Arvi-Matti Kuusniemi et al., “Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic change”, Kidney International, vol. 68, (2005) pp. 121-132.
Anthony G. W. Norden et al., “Urinary Megalin Deficiency Implicates Abnormal Tubular Endocytic Function in Fanconi Syndrome”, J. Am. Soc. Nephrol. 13: 125-133, 2002.
K. Kobayashi et al., “Conditions for Solubilization of Tamm-Horsfall Protein/Uromodulin In Human Urine and Establishment of a Sensitive and Accurate Enzyme-Linked Immunosorbent Assay (ELISA) Method”, Archives of Biochemistry and Biophysics, vol. 388, No. 1, Apr. 1, 2001, pp. 113-120.
C.J. Ilsa Raats et al., “Reduction in Glomerular Heparan Sulfate Correlates with Complement Deposition and Albuminuria in Active Heymann Nephritis”, J. Am. Soc. Nephrol. 10: 1689-1699, 1999.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for measuring human megalin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for measuring human megalin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for measuring human megalin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2645836

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.