Piperazines and piperidines as Mglur5 potentiators

Details Piperazines and piperidines as Mglur5 potentiators Piperazines and piperidines as Mglur5 potentiators

2011-05-03

2011-05-03

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252140, C514S254020, C514S253010, C514S254050, C514S315000, C514S255010, C544S366000, C544S391000, C544S359000, C544S360000, C544S369000, C544S379000, C546S228000

Reexamination Certificate

active

07935703

ABSTRACT:
Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof:wherein Ar1, Ar2, A, X, Y, m, n and R1, R2, R3, R4and R5are as described in the specification, processes for their preparation, pharmaceutical formulations comprising them and their use in therapy, particularly in the therapy of neurological and psychiatric disorders associated with glutamate dysfunction.

REFERENCES:
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patent: WO-2006/002349 (2006-01-01), None
patent: WO 2006002349 (2006-01-01), None
Pietraszek, et al., mGLuR5, but not mGluR1, Antagonistic Modifies MK-801-induced Locomotor Activity and Deficit of Prepulse Inhibition, Neuropharmacology, 49, 73-85 (2005).

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