Magnetically actuated microfluidic mixers

Fluid handling – Flow affected by fluid contact – energy field or coanda effect – Means to regulate or vary operation of device

Reexamination Certificate

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Details

C251S121000, C251S129140, C138S046000, C366S349000

Reexamination Certificate

active

07992591

ABSTRACT:
In one embodiment as described in this section, an apparatus for mixing of microfluidic streams on a chip is presented, which comprises a micro-channel and a plurality of magnetic valves on the chip. A guiding magnet produces a proximal magnetic field gradient to exert a force on a bead in a cavity when placed at in a vicinity of the chip. The bead-cavity combination form a magnetic valve. In one embodiment, the mouth of the cavity is tapered so to prevent the magnetic bead from completely blocking the corresponding micro-channel section to enhance the mixing of microfluidic streams at the narrowed fluid path. In one embodiment, magnetically actuated valves direct the flow in a microfluidic system in one of several flow paths wherein the mixing characteristics of the paths are different.

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patent: 6606922 (2003-08-01), Case et al.
patent: 6802489 (2004-10-01), Marr et al.
patent: 6981518 (2006-01-01), Gilbert et al.
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patent: 2004/0265150 (2004-12-01), McElfresh et al.
patent: 2005/0116798 (2005-06-01), Bintoro et al.
patent: 2010/0140517 (2010-06-01), Delamarche
patent: 2010/0143193 (2010-06-01), Delamarche

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