Topical application agents against mimic and age-related...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S537000

Reexamination Certificate

active

07964630

ABSTRACT:
The compounds of formula (I)whereinX represents a bond or NH—CH(C═O)—(CH2)3+n—NH—R5,n represents 0, 1 or 2,R1, R4and R5—independently from each other—represent hydrogen, possibly substituted C1-C6-alkyl, amidino or tetra-C1-C6-alkylamidinium,R2represents hydrogen or possibly substituted C1-C6-alkylor R1and R2together with the residue to which they are bound represent a 5- to 7-membered, saturated ring,R3represents C1-C12-alkoxy, C1-C12-alkylamino, possibly substituted aryl-C1-C6-alkylamino, possibly substituted heteroaryl-C1-C6-alkylamino, possibly substituted aryl-C1-C6-alkoxy or possibly substituted heteroaryl-C1-C6-alkoxy, andR6represents hydrogen or, when n is 1, also amino or together with R1and the residue to which R6and R1are bound a 5- to 7-membered, saturated ring, as well as their physiologically acceptable salts are new. They can be manufactured according to common methods and processed to topically applicable compositions that are appropriate for treating mimic and age-related wrinkles in human skin.

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Ito et al., In vitro non-thrombogenicity of a thrombin-substrate-immobilized polymer surface by the inhibition of thrombin activity, 1991, J. Biomater. Sci. Polymer Edn, vol. 2, No. 2, pp. 123-138.
Hirase et al., N-Terminal tripeptide analogs of fibrin alpha-chain and their inhibitory effects on fibrinogen/thrombin clotting, 1989, Peptide Chemistry, Volume Date 1988, 26th, pp. 31-34.

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