Use of secretor, Lewis and sialyl antigen levels in clinical...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C436S518000

Reexamination Certificate

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07871785

ABSTRACT:
An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1 , H-2, Lewisband Lewisyantigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).

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Gokman-Polar et al (Cancer Research 61:1375-1381, 2001).
Ikehara et al., “Polymorphisms of Two Fucosyltransferase Genes (Lewis and Secretor Genes) Involving Type 1 Lewis Antigens Are Associates with the Presence of Anti-Helicobacter pyloriIgG Antibody,” Cancer Epidemiology, Biomarkers & Prevention, vol. 10, pp. 971-977 (2001).
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