Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2011-02-01
2011-02-01
Saoud, Christine J (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C530S350000, C436S501000
Reexamination Certificate
active
07879978
ABSTRACT:
Isolated polynucleotides encodingMacaca fascicularisST2L (Cyno ST2L), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed.
REFERENCES:
patent: 6323334 (2001-11-01), Kingsbury et al.
Tominaga, et al., “A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor,” FEBS Letters, 258(2):301-304 (1989).
Meisel et al., “Regulation and Function of T1/ST2 Expression on CD4 T Cells: Induction of Type 2 Cytokine Production by T1/ST2 Cross-Linking,” Journal of Immunology, 166:3143-3150 (2001).
Trajkovic et al., “T1/ST2—an IL-1 receptor-like modulator of immune responses,” Cytokine Growth Factor Reviews, 15:87-95 (2004).
Schmitz et al., “IL-33, an Interkeukin-1-like-Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines,” Immunity, 23:479-490 (2005).
Kakkar, et al., “The IL-33/ST2 pathway: therapeutic target and novel biomarker,” Nature Reviews 7:827-840 (2008).
Coyle et al., “Crucial Role of the Interleukin 1 Receptor Family Member T1/ST2 in T Helper Cell Type 2-mediated Lung Mucosal Immune Responses,” Journal of Experimental Medicine, 190:895-902 (1999).
Hayakawa et al., “Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation,” Journal of Biological Chemistry, 282(36):26369-26380 (2007).
Leung et al., “A Novel Therapy of Murine Collagen-Induced Arthritis with Soluble T1/ST2,” Journal of Immunology, 173:145-150 (2004).
Shimizu, et al., “Functional SNPs in the distal promoter of theST2gene are associated with atopic dermatitis,” Human Molecular Genetics, 14(19):2919-2927 (2005).
GenBank Accession No. NM—016232.4 (1992).
Cotty Adam
Fursov Natalie
Naso Michael
Baumeister Kirk
Centocor Ortho Biotech Inc.
Saoud Christine J
Seharaseyon Jegatheesan
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