Hepatitis B virus pre-S1 derived synthetic polypeptides and...

Details Hepatitis B virus pre-S1 derived synthetic polypeptides and... Hepatitis B virus pre-S1 derived synthetic polypeptides and...

2011-02-22

2011-02-22

Peng, Bo (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S005000, C435S007210, C424S184100, C424S189100

Reexamination Certificate

active

07892754

ABSTRACT:
The invention relates to a group of synthetic polypeptides, derived from the pre-S1 region of HBV, that efficiently interfere with early steps of an HBV infection. The peptides of the invention can be used in diagnostics for the detection of antigens and/or antibodies.

REFERENCES:
patent: 5158769 (1992-10-01), Neurath et al.
Kramvis A, Kew MC. “Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy.” J Viral Hepat. Sep. 2005;12(5):456-64.
Gripon P, et al. “Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein.” J Virol. Feb. 2005;79(3):1613-22.
Keller, MA, “Passive immunity in prevention and treatment of infectious disease.” Clin Microbiol Rev. Oct. 2000;13(4):602-14.
Engelke et al. “Characterization of a hepatitis B and hepatitis delta virus receptor binding site.” Hepatplogy, Apr. 2006;43(4):750-60.
Kidd-Ljunggren K, et al. “Generic variability in hepatitis B viruses.” J Gen Virol. Jun. 2002;83(Pt 6):1267-80. Review.
Neurath AR et al. “Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus” Cell, 46:429-436, 1986.

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