Preparation for use of aspartate and vitamin B12 or biotin...

Details Preparation for use of aspartate and vitamin B12 or biotin... Preparation for use of aspartate and vitamin B12 or biotin...

2011-08-23

2011-08-23

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000

Reexamination Certificate

active

08003600

ABSTRACT:
It has been found that high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, especially in relative absence of glutamate equivalents, improve the metabolism of ketobodies and/or lactate in a mammal's body, especially in diseased or traumatic conditions. As a result, levels of ketobodies and lactate can be decreased and unphysicologically high acidity normalized. Thus, it is an object of the invention to provide an enteral nutritional or a pharmaceutical composition for the treatment and/or prevention of disturbed ketone and lactate metabolism, i.e. elevated concentrations of ketone bodies, lactate and/or other organic acids and/or insufficient pH homeostasis, especially elevated concentrations of ketone bodies and/or lactate, in a mammal's blood, wherein the composition comprises high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, preferably in relative absence of glutamate equivalents.

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Database Medline ′Online! US National Library of Medicine (NLM), Feb. 2004, Hou Jia-woei: “Biotin responsive multiple carboxylase deficiency presenting as diabetic ketoacidosis,” XP002367079.
Nosadine, R. et al, “A possible mechanism for the anti-ketogenic action of alanine in the rat.” Biochem. J. (1980), 190-323-332.
Englyst and Cummings, Adv. Exp. Med. Biol. 270-225 (1990).

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