Potentiating the effect of compound comprising nitric oxide

Details Potentiating the effect of compound comprising nitric oxide Potentiating the effect of compound comprising nitric oxide

2011-05-17

2011-05-17

Henley, III, Raymond (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S509000, C424S718000

Reexamination Certificate

active

07943667

ABSTRACT:
Treatment of or prophylaxis against the occurrence of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction or infection in the lungs comprises administration into the lung(s) as a gas composition comprising nitric oxide, e.g. ethyl nitrite or nitric oxide, and also administering into the lungs L-cysteine. The pulmonary disorder can be persistent pulmonary hypertension of the newborn to increase SpO2 and decrease systolic blood pressure. In another case administration is to a premature newborn to prophylax against the development of bronchopulmonary dysplasia.

REFERENCES:
patent: 5485827 (1996-01-01), Zapol et al.
patent: 2004/0224899 (2004-11-01), Gaston et al.
S. Singh et al., Nitric oxide, the biological mediator of the decade: fact or fiction?, European Respiratory Journal, 1997, pp. 699-707.

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