Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems
Reexamination Certificate
2011-01-25
2011-01-25
Getzow, Scott M (Department: 3762)
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Electrical therapeutic systems
Reexamination Certificate
active
07877147
ABSTRACT:
Apparatus for modifying a property of a brain of a patient is provided, including one or more electrodes (7), adapted to be applied to a site selected from a group of sites consisting of: a sphenopalatine ganglion (SPG) (6) of the patient and a neural tract originating in or leading to the SPG. A control unit (8) is adapted to drive the one or more electrodes to apply a current to the site capable of inducing (a) an increase in permeability of a blood-brain barrier (BBB) of the patient, (b) a change in cerebral blood flow of the patient, and/or (c) an inhibition of parasympathetic activity of the SPG.
REFERENCES:
patent: 4907602 (1990-03-01), Sanders
patent: 5540734 (1996-07-01), Zabara
patent: 5792067 (1998-08-01), Karell
patent: 5792100 (1998-08-01), Shantha
patent: 6066163 (2000-05-01), John
patent: 6208894 (2001-03-01), Schulman et al.
patent: 6735474 (2004-05-01), Loeb et al.
patent: 6922590 (2005-07-01), Whitehurst
patent: 2002/0099417 (2002-07-01), Naritoku
patent: 2003/0036781 (2003-02-01), Nuttin et al.
patent: 2003/0176892 (2003-09-01), Shalev
patent: 2004/0133248 (2004-07-01), Frei et al.
patent: 2004/0220644 (2004-11-01), Shalev et al.
patent: 1 559 369 (2005-08-01), None
patent: WO 03/105658 (2003-12-01), None
patent: WO 2004/064918 (2004-08-01), None
Japanese Office Action dated Sep. 16, 2008, which issued during the prosecution of Applicant's Japanese Patent Application No. 2001-581749.
Hotta H et al., in an article entitled, “Effects of stimulating the nucleus basalis of Meynert on blood flow and delayed neuronal death following transient ischemia in rat cerebral cortes,” Jap J Phys 52:383-393 (2002).
Segher O et al., in an article entitled, “Spinal cord stimulation reducing infract volume in model of focal cerebral ischemia in rats,” J Neurosurg 99(1):131-137 (2003).
Goadsby PJ et al., “Effect of stimulation of trigeminal ganglion on regional cerebral blood flow in cats,” Am J Physiol 22:R270-R274 (1987).
Matsui T et al., in an article entitled, “The effects of cervical spinal cord stimulation (cSCS) on experimental stroke,” Pacing Clin Electrophysiol 12(4 Pt 2):726-32 (1989).
Suzuki N. et al., “Trigeminal fibre collaterals storing substance P and calcitonin gene-related peptide associate with ganglion cells containing choline acetyltransferase and vasoactive intestinal polypeptide in the sphenopalatine ganglion of the rat. An axon reflex modulating parasympathetic ganglionic activity?” Neuroscience 30:595-604 (1989).
Walters BB et al., “Cerebrovascular projections from the sphenopalatine and otic ganglia to the middle cerebral artery of the cat,” Stroke 17:488-494 (1986).
Sun Y et al., “Neuronal nitric oxide synthase and ischemia-induced neurogenesis,” J Cereb Blood Flow Metab 25(4):485-92 (2005).
Zhang F et al., “Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia,” J Cereb Blood Flow Metab 14(2):217-26 (1994).
Schmid-Elsaesser R et al., “A critical reevaluation of the intraluminal thread model of focal cerebral ischemia. Evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-Doppler flowmetry,” Stroke 29:21622170 (1998).
Jolliet-Riant P, Tillement JP, “Drug transfer across the blood-brain barrier and improvement of brain delivery,” Fundam. Clin. Pharmacol., 13, 16-25 (1999).
Varghese et al., “Endoscopic transnasal neurolytic sphenopalatine ganglion block for head and neck cancer pain,” J Laryngol Otol 115(5):385-7 (2001).
Roman GC, “Cholinergic dysfunction in vascular dementia,” Curr Psychiatry Rep 7(1):18-26 (2005).
Van Gijn J et al., “Subarachnoid haemorrhage: diagnosis, causes and management,” Brain 124:249-278 (2001).
Suzuki, N. et al., “Selective Electrical Stimulation of postganglionic Cerebrovascular Parasympathetic Nerve Fibers Originating from the Sphenopalatine Ganglion Enhances Cortical Blood Flow in the Rat”, Journal of Cerebral Blood Flow and Metabolism, 10, 383-391 (1990).
Samad TA et al., in an article entitled, “Interleukin-lbeta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity,” in Nature 410(6827):471-5 (2001).
Van de WaterBeemd, et al., “Estimation of Blood Brain Barrier Crossing of Drugs Using Molecular Size and Shape and H bonding Descriptors”, Journal of Drug Targeting, 6, 151-165, 1998.
Davis SM et al., “Advances in penumbra imaging with MR,” Cerebrovasc Dis 17 Suppl 3:23-7 (2004).
Zausinger VS et al., “Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms,” Brain Research 863(1-2):94-105 (2000).
Phan TG et al., “Salvaging the ischaemic penumbra: more than just reperfusion?” Clin Exp Pharmacol Physiol 29(1-2):1-10 (2002).
Zhang ZG et el., “VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain,” J Clin Invest 106:829-838 (2000).
Kawamata T et al., “Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat,” J Cereb Blood Flow Metab 16:542-547 (1996).
Ziche M et al., “Nitric oxide and angiogenesis,” J Neurooncol 50:139-148 (2000).
Zhang R et al., “A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats,” Ann Neurol 50:602-611 (2001).
de la Torre JC, “Vascular basis of Alzheimer's pathogenesis,” Ann NY Acad Sci 977:196-215 (2002).
Hunter AJ et al., “To what extent have functional studies of ischemia in animals been useful in the assessment of potential neuroprotective agents?” Trends Pharmacol Sci 19:59-66 (1998).
Kanner AA et al., “Serum S100beta: a noninvasive marker of blood-brain barrier function and brain lesions,” Cancer 97(11):2806-13 (2003).
Tony JFL, “Nitric oxide and the cerebral vascular function,” J Biomed Sci 7:16-26 (2000).
Sandgren K et al., “Vasoactive intestinal peptide and nitric oxide promote survival of adult rat myenteric neurons in culture,” J Neurosci Res 72(5):595-602 (2003).
Laude K et al., “NO produced by endothelial NO synthase is a mediator of delayed preconditioning-induced endothelial protection,” Am J Physiol Heart Circ Physiol 284(6):H2053-60 (2003) (Epub Jan. 9, 2003).
Khan M et al., “S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke,” J Cereb Blood Flow Metab 25(2):177-92 (2005).
Pluta RM, “Delayed cerebral vasospasm and nitric oxide: review, new hypothesis, and proposed treatment,” Pharmacol Ther 105(1):23-56 (2005).
Reis DJ et al., “Electrical stimulation of cerebellar fastigial nucleus reduces ischemic infarction elicited by middle cerebral artery occlusion in rat,” J Cereb Blood Flow Metab 11(5):810-8 (1991).
Nollet H et al., “Transcranial magnetic stimulation: review of the technique, basic principles and applications,” The Veterinary Journal 166:28-42 (2003).
Devoghel JC, “Cluster headache and sphenopalatine block,” Acta Anaesthesiol Belg., 32(1):101-7 (1981)—an abstract.
An Office Action dated Jul. 16, 2008, which issued during the prosecution of Applicant's U.S. Appl. No. 11/349,020.
An Office Action dated Jun. 27, 2008, which issued during the prosecution of Applicant's U.S. Appl. No. 10/518,322.
A Supplementary European Search Report dated Oct. 27, 2009, which issued during the prosecution of Applicant's European Patent Application No. 04 77 0568.
Gross Yossi
Shalev Alon
Abelman ,Frayne & Schwab
Brainsgate Ltd.
Getzow Scott M
LandOfFree
Stimulation of the sphenopalatine ganglion for treating... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stimulation of the sphenopalatine ganglion for treating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stimulation of the sphenopalatine ganglion for treating... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2627161