Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-02-22
2011-02-22
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S117000
Reexamination Certificate
active
07893060
ABSTRACT:
Thiazolopyrimidines of formula (I): wherein W represents a thiazole ring; R1and R2form, together with the N atom to which they are attached, a group of the following formula (IIa): in which A is a ring system; m is 0, 1 or 2; R3is H or C1-C6alkyl; and R4is an indole group which is unsubstituted or substituted; and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PD kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
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Beswick Mandy Christine
Blench Toby Jonathan
Dechaux Elsa Amandine
Hancox Timothy Colin
Kulagowski Janusz Jozef
Anderson Rebecca L
Andrus Alex
F. Hoffmann-La Roche AG
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