Selection of cells expressing heteromeric polypeptides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S070100, C435S320100, C435S326000, C435S364000, C435S365000, C435S372100, C536S023530

Reexamination Certificate

active

07968313

ABSTRACT:
This invention is in the general field of recombinant expression of polypeptides in animal cell culture. More particularly, the invention concerns improved selection in cells of recombinantly engineered vectors designed to express polypeptides.

REFERENCES:
patent: 5624818 (1997-04-01), Eisenman et al.
patent: 5840869 (1998-11-01), Mosley et al.
patent: 5916771 (1999-06-01), Hori et al.
patent: 5928904 (1999-07-01), Holmes et al.
patent: 6270964 (2001-08-01), Michnick et al.
patent: 6294330 (2001-09-01), Michnick et al.
patent: 6428951 (2002-08-01), Michnick et al.
patent: 7691605 (2010-04-01), McGrew et al.
patent: 2003/0082735 (2003-05-01), McGrew et al.
patent: 2007/0031422 (2007-02-01), McGrew et al.
patent: WO 98/13502 (1998-04-01), None
patent: WO 98/34120 (1998-08-01), None
patent: WO 98/44350 (1998-10-01), None
patent: WO 01/27299 (2001-04-01), None
patent: WO 01/38557 (2001-05-01), None
Murre et al., Interactions between Heterologous Helix-Loop-Helix Proteins Generate Complexes That Bind Specifically to a Common DNA SequenceCell58:537-544 (1989).
Wood et al., High Level Synthesis of Immunoglobulins in Chinese Hamster Ovary CellsJ. I.145:3011-3018 (1990).
Marnionstein et al., DNA recognition by GAL4: structure of a protein-DNA complexNature356:408-414 (1992).
Kurokawa et al., Differential orientations of the DNA-binding domain and carboxy-terminal dimerizaton interface regulate binding site selection by nuclear receptor heterodimersGenes Dev7:1423-1435 (1993).
Zhang et al., Antibody promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1Proc. Natl. Acad Sci USA90:285-2855 (1993).
Nixon et al., Assembly of an active enzyme by the linkage of two protein modulesProc. Natl. Acad Sci94:1069-1073 (1997).
Pelletier et al., Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragramentsProc. Natl. Acad. Sci95:12141-12146 (1998).
Remy and Michnick , Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assaysProc. Natl. Acad.Sci96:5394-5399 (1999).
Arndt et al., A Heterodimeric Coiled-coil Peptide Pair Selected in Vivo from a Designed Library-versus-Library EnsembleJMB295:627-639 (2000).
Morimoto et al., High level expression of a human rabies virus-neutralizing monoclonal antibody by a rhabdovirus-based vectorJ. of Imm. Methods252:199-206 (2001).
Remy and Michnick, Visualization of biochemical networks in living cellsProc. Natl. Acad. Sci98:7678-7683 (2001).
Mossner et al., “Fast selection of antibodies without antigen purification: adaptation of the protein fragment complementation assay to select antigen-antibody pairs” J of Molecular Biology, 308,2:115-122 (2001).
Lucas, et al., “High-level production of recombinant proteins in CHO cells using a dicistronic DHRF intron expression vector”Nucleic Acids Research,Oxford University Press, 24, 9: 1174-1179 (1996).
Bianchi, et al., “High-level expression of full-length antibodies using trans-complementing expression vectors.” Biotechnology and Bioengineering, 84, 4: 439-444 (2003).

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