Surgery – Blood drawn and replaced or treated and returned to body
Reexamination Certificate
1998-01-26
2001-10-23
Sykes, Angela D. (Department: 3762)
Surgery
Blood drawn and replaced or treated and returned to body
C604S007000, C604S005010, C604S030000, C604S065000, C604S067000, C604S407000, C222S095000
Reexamination Certificate
active
06306113
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a method for mixing blood and an auxiliary liquid for reperfusion of blood vessels and also relates to a reperfusion device.
2. Description of the Related Art
DE 3,820,840 C1 discloses an aqueous reperfusion solution for preventing reperfusion damage following acute, peripheral vessel obstruction in a patient. EP 0,513,071 B1 discloses a reperfusion device for reperfusion of blood vessels. That device has the following features: a catheter which can be introduced into a blood vessel, a blood withdrawal device for withdrawing oxygenated arterial blood from a patient, means for mixing a reperfusion solution with the blood withdrawn from the patient, a mechanical pump device for delivering the mixture of blood and reperfusion solution through the catheter into the blood vessel, and pressure measurement means arranged at the tip of the catheter and in the form of a pressure measurement lumen or a pressure probe. Various methods are known for eliminating blood vessel obstructions. However, despite successful restoration of the blood flow, the morbidity and mortality rates are still relatively high after such a vascular intervention. The main reason for this is reperfusion damage, i.e., a tissue lesion which occurs upon the vessel obstruction being eliminated, if the blood starts to flow through the artery again at the full arterial pressure generated by the heart. This disadvantage is avoided or is substantially reduced by using the reperfusion solution, after the vessel obstruction has been eliminated. This reperfusion solution is introduced, for example by using a reperfusion device, into the vessel over a longer period of time, e.g. over 30 minutes, and at a reduced pressure, before the vessel is once again loaded with the full arterial pressure.
SUMMARY OF THE INVENTION
The object of invention is to perform reperfusion using means which are less expensive and easier to handle than known methods and devices.
In a reperfusion device for reperfusion of a blood vessel, blood is withdrawn from a patient and is metered into a first compressible bag. The first bag is connected with a second compressible bag. Compression of the first bag transfers blood from the first bag to the second bag. The second bag is also compressible and is connected with a supply container for metered supply of reperfusion liquid which is mixed with the blood that enters the second bag. The mixture of blood and reperfusion liquid is transferred in a metered amount from the second bag through a reperfusion catheter into a blood vessel by compressing the second bag. The bags are compressed either manually or by respective pressure cuffs. Hose clamps are provided on the tubing between the bags and on the reperfusion catheter. Meters measure and indicate the flow into and out of each of the bags and through the reperfusion catheter.
The invention provides a method and a device, and particularly provides a set of components for reperfusion, particularly for reperfusion of a patient's leg. The set is more acceptable for vascular surgery than are previously known means, because of low production costs and ease of handling. In principle, the set involves the use of two bags. The first bag is filled with blood from the iliac artery. This blood is then conveyed into the second bag, into which a defined amount of a reperfusion liquid had been placed earlier. This mixture of blood and reperfusion liquid is then passed into the leg artery over a predetermined period of time and at a pre-determined pressure selected so as to avoid producing a lesion in the vessel. This procedure is repeated several times. This is done without use of a pump, because each bag is compressed directly by hand or indirectly via a compressed air cuff which is operated by hand. The blood pressure is measured either in the delivery line from the second bag to the leg or in a delivery cannula which introduces mixture into the leg artery. Depending on the pressure value of the blood in the leg artery, the pressure in the delivery line is regulated by exerting greater or lesser pressure on the second bag. Since no heparin is provided in this treatment, all bags, tubings, catheters and other elements coming into contact with the blood, or with the mixture of blood and reperfusion liquid, must be equipped with a heparin coating.
Other features and advantages of the present invention will become apparent from the following description of the invention which refers to the accompanying drawings.
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Bianco Patricia M
Ostrolenk Faber Gerb & Soffen, LLP
Sykes Angela D.
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