Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Patent
1996-09-04
2000-05-16
Hauda, Karen M.
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
800 4, 800 18, 800 21, 800 25, 435375, 435325, 435355, 4353723, 424 931, C12N 500, C12N 1563, C12N 1509, A61K 4800
Patent
active
060639830
ABSTRACT:
A monoclonal preparation of lymphocytes, their production and use.
REFERENCES:
Winandy et al. Cul 83:289, 1995, May, 27, 1997.
Adams, B. et al. "Pax-5- encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis" Genes & Development 6: 1589-1607 (1992).
Akbar, A.N. et al. "A possible role for bcl-2 in regulating T-cell memory--a `balancing act` between cell death and survival" Immunology Today 14(11): 526-531 (1993).
Ardavin, C. et al. "Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population" Nature 362; 761-763 (1993).
Asarnow, D.M. et al. "Limited Diversity of .gamma..delta. Antigen Receptor Genes of Thy-1.sup.+ Dendritic Epidermal Cells" Cell 55: 837-847 (Dec. 2, 1988).
Beg, A.A. et al. "The I.kappa.B proteins: multifunctional regulators of Rel/NF-.kappa.B transcription factors" Genes & Development 7: 2064-2070 (1993).
Bigby, M. et al. "Ratio of Langerhan Cells to Thy-1.sup.+ Dendritic Epidermal Cells in Murine Epidermis Influences the Intensity of Contact Hypersensitivity" The Journal of Investigative Dermatology 89(5):495-499 (Nov. 1987).
Boise, L.H. et al. "bcl-.times., a bcl-2-Related Gene that Functions as a Dominant Regulator of Apoptotic Cell Death" Cell 74: 597-608 (1993).
Bours, V. et al. "The Oncoprotein Bcl-3 Directly Transactivates through .kappa.B Motifs via Association with DNA-Binding p50B Homodimers" Cell 72: 729-739 (1993).
Cepko, C.L. et al "Construction and Applications of a Highly Transmissible Murine Retrovirus Shuttle Vector" Cell 37: 1053-1062 (1984).
Clevers, H.C. et al. "Transcription factors in early T-cell development" Immunology Today 14(2): 591-596 (1993).
Connelly, C.S. et al. "The Role of Transgenic Animals in the Analysis of Various Biological Aspects of Normal and Pathologic States" Experimental Cell Research 183: 257-276 (1989).
Delwel, R. et al. Four of the Seven Zinc Fingers of the Evi-1 Myeloid-Transforming Gene Are Required for Sequence-Specific Binding to GA(C/T)AAGA(T/C)AAGATAA, Molecular and Cellular Biology 13(7): 4291-4300 (1993).
Ehlich, A. et al. "Immunoglobulin Heavy and Light Chain Genes Rearrange Independently at Early Stages of B Cell Development" Cell 72: 695-704 (1993).
Fife, A. et al. "Gram negative septicaemia diagnosed on peripheral blood smear appearances" Journal of Clinical Pathology 47:82-84 (1994).
Fleming, W.H. et al. "Functional Heterogeneity Is Associated with the Cell Cycle Status of Murine Hematopoietic Stem Cells" J. Cell Biol. 122: 897-902 (1993).
Franzoso, G. et al. "The oncoprotein Bcl-3 can facilitate NF-.kappa.B-mediated transactivation by removing inhibiting p50 homodimers from select .kappa.B sites" The EMBO Journal, vol. 12, No. 10 3893-3901 (1993).
Furley, A.J. et al. "Developmentally Regulated Rearrangement and Expression of Genes Encoding the T Cell Receptor-T3 Complex" Cell, vol. 46: 75-87 (Jul. 1986).
Garni-Wagner, B.A. et al. "Natural Killer Cells in the Thymus" The Journal of Immunology 144(3): 796-803 (1990).
Georgopoulos, K. et al. "Functionally Distinct Isoforms of the CRE-BP DNA-Binding Protein Mediate Activity of a T-Cell-Specific Enhancer" Molecular and Cellular Biology 12(2): 747-757 (Feb. 1992).
Georgopoulos, K. et al. "A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3' end of the CD3-.delta. gene" The EMBO Journal 7(8): 2401-2407 (Aug. 1988).
Godfrey, D.I. and A. Zlotnik "Control points in early T-cell development" Immunology Today 14(11): 547-553 (1993).
Gogos, J.A. et al. "Sequence Discrimination by Alternatively Spliced Isoforms of a DNA Binding Zinc Finger Domain" Science 257: 1951-1955 (1992).
Hackett, Jr., J. et al. "Origin and Differentiation of Natural Killer Cells" The Journal of Immunology 136(8): 3124-3131 (1986).
Hackett, Jr., J. et al. "Transplantable progenitors of natural killer cells are distinct from those of T and B lymphocytes" Proc. Natl. Acad. Sci USA 83: 3427-3431 (1986).
Hardy, R.R. et al. "Resolution and Characterization of Pro-B and Pre-Pro-B Cell Stages in Normal Mouse Bone Marrow" J. Exp. Med. 173: 1213-1225 (May 1991).
Havran, W.L. and J.P. Allison. "Developmentally ordered appearance of thymocytes expressing different T-cells antigen receptors" Nature 335: 443-445 (1988).
Havran, W.L. and J.P. Allision "Origin of Thy-1 + dendritic epidermal cells of adult mice from fetal thymic precursors" Nature 344: 68-70 (1990).
Havran, W.L. et al. "Limited diversity of T-cell receptor .gamma.-chain expression of murine Thy-1 +dendritic epidermal cells revealed by V.gamma.3-specific monoclonal antibody" Proc. Natl. Acad. Sci. USA 86: 4185-4189 (1989).
Haynes, B. et al. "Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development" Immunology Today 10(3): 87-90(1989).
Hestdal, K. et al. "Characterization and Regulation of RB6-8C5 Antigen Expression on Murine Bone Marrow Cells" J. Immunol. 147(1): 22-28 (Jul. 1, 1991).
Ho, I.-C. et al. "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor .alpha. gene" The EMBO Journal 10(5): 1187-1192 (1991).
Ho, I.-C. et al. "Sequence-Specific Binding of Human Ets-1 to the T Cell Receptor .alpha. Gene Enhancer" Science 250: 814-818 (1990).
Hsu, T. et al. "Multiple Zinc Finger Forms Resulting from Developmentally Regulated Alternative Splicing of a Transcription Factor Gene" Science 257: 1946-1950 (1992).
Ikuta, K. et al. "A Developmental Switch in Thymic Lymphocyte Maturation Potential Occurs at the Level of Hematopoietic Stem Cells" Cell 62: 863-874 (1990).
Ikuta, K. et al. "Lymphocyte Development From Stem Cells" Annu. Rev. Immunol. 10: 759-783 (1992).
Jiang, J. and M. Levine "Binding Affinities and Cooperative Interactions with bHLH Activators Delimit Threshold Responses to the Dorsal Gradient Morphogen" Cell 72: 741-752 (1993).
Juhlin, L. and W.B. Shelley "New Staining Techniques for the Langerhans Cell" Acta Dermatovener 57: 289-296 (1977).
Kang, S.-M. et al. "NF-.kappa.B Subunit Regulation in Nontransformed CD4.sup.+ T Lymphocytes" Science 256: 1452-1456 (1992).
Karasuyama, H. et al. "The Expression of V.sub.pre-B /.lambda.5 Surrogate Light Chain in Early Bone Marrow Precursor B Cells of Normal and B Cell-Deficient Mutant Mice" Cell 77: 133-143 (Apr. 8, 1994).
Lagasse, E. and I.L. Weissman "BCL-2 Tansgene Inhibits Neutrophils Cell Death But Not Their Engulfment By Microphages" J. Biochem. 0 (Suppl. 17D): 168 (Mar. 13-31, 1993).
Leiden, J.M. "Transcriptional regulation during T-cell development: The .alpha. TCR gene as a molecular model" Immunology Today 13(1): (Jan. 22-30, 1992).
Lenardo, M.J. and D. Baltimore "NF-.kappa.B: A Pleiotropic Mediator of Inducible and Tissue-Specific Gene Control" Cell 58: 227-229 (1989).
Li, E. et al. "Targeted Mutation of the DNA Methyltransferase Gene Results in Embryonic Lethality" Cell 69: 915-926 (1992).
Li, Y.-S. et al. "The Regulated Expression of B Lineage Associated Genes during B Cell Differentiation in Bone Marrow and Fetal Liver" J. Exp. Med. 178: 951-960 (1993).
Liang, P. et al. "Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization" Nucleic Acids Research 21(14): 3269-3275 (1993).
Mann, R. et al. "Construction of a Retrovirus Packaging Mutant and Its Use to Produce Helper-Free Defective Retrovirus" Cell 33: 153-159 (1993).
Martin, D.I.K. et al. "Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages" Nature 344: 444-447 (1990).
McDonnell, T.J. and S.J. Korsmeyer "Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)" Nature 349: 254-256 (1991).
McDonnell, T.J. et al. "bcl-2-Immunoglobulin Transgenic Mice Demonstrate Extended B Cell Survival and Follicular Lymphoproliferation" Cell 57: 79-88 (1989).
Metcalf, D. "The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells" Nature 339:27-30 (1989).
Mombaerts, P. et al. "RAG-1-Deficient Mice Have No Mature B and T Lymphocytes" Cell 68: 869-877 (19
Hauda Karen M.
The General Hospital Corporation
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