Thermal effect patch and the use thereof

Details Thermal effect patch and the use thereof Thermal effect patch and the use thereof

1999-03-19

2001-02-20

Lewis, Kim M. (Department: 3764)

Surgery: splint, brace, or bandage

Bandage structure

Skin laceration or wound cover

C602S002000, C602S043000, C602S054000

Reexamination Certificate

active

06191339

ABSTRACT:

The present invention relates to a patch for temporary application to the skin to exert cosmetic and/or pharmaceutical treatment action thereon.
BACKGROUND OF THE INVENTION
Patches are known that comprise a backing sheet coated on one face in a reservoir-forming layer known as a “matrix”, containing one or more active substances for diffusing into the skin and/or for acting thereon.
The invention relates more particularly to a patch in which the matrix is made of a material that has intrinsic adhesive properties.
Selecting this material gives rise to difficulties, in particular:
it must be capable of containing the active substance(s) for acting on the skin;
its adhesion to the skin must not be too strong, particularly if it is to be applied in repeated manner, since otherwise the region of the body on which the patch is applied will become irritated and removing the patch will become painful;
its adhesion must not be too weak either, since otherwise it will not be able to adhere to the skin if it is moist or if it becomes moist, e.g. because of sweating;
it must be sufficiently flexible to allow the patch to fit over the shape of the region of the body on which it is applied;
it must remain on the backing sheet when the patch is removed; and
finally, it must make it possible to extract the impurities that are to be found on the surface of the skin, in particular sebum or sweat.
In spite of these difficulties, several materials have been proposed for making the matrix, however they are not necessarily suitable for all of the active substances that it might be desirable to incorporate therein.
French patent 2 738 744 or European patent 0 309 309 teach in particular the use of hydrophobic or hyposoluble materials for constituting the matrix.
The hydrosoluble material described in European patent 0 309 309 is relatively impractical in use since it does not present the required adhesive properties prior to application to the skin and it requires the skin to be previously moistened.
OBJECTS AND SUMMARY OF THE INVENTION
The present invention seeks to propose a novel patch whose matrix-constituting material satisfies the requirements listed above and for which diffusion into the skin and/or action on the skin of the active substances contained therein is improved.
The patch of the invention comprises:
a reflecting layer that reflects the infrared radiation released by the human body, and between said reflecting layer and said face for application to the skin:
a matrix made of a material having self-adhesive properties and comprising at least an acrylic or vinyl polymer whose adhesive properties increase with temperature over the range 20° C. to 40° C.; and
in said matrix at least one active substance having an effect on the skin.
By means of the invention, the temperature at the interface between the skin and the patch rises quickly, because the thermal radiation released by the body is reflected by the reflecting layer.
This can have multiple advantageous effects, and in particular this can:
significantly increase the temperature of the matrix, and given the particular material selected for making it, reinforce its adhesion to the skin;
enhance diffusion of the active substance(s) within the matrix; and
increase blood circulation beneath the patch, which can be favorable to the penetration and/or action of said active substances.
In a particular embodiment of the invention, the matrix is secured to a backing sheet and the reflecting layer is situated on said backing sheet.
Preferably, the reflecting layer is then formed by metallizing at least one of the faces of said backing sheet.
In a particular embodiment of the invention, the patch further comprises a permeable structure such as a net that is embedded at least in part in the matrix so as to modify its overall adhesive power.
In a particular embodiment, the patch further comprises a layer suitable for picking up thermal energy from external radiation.
The invention also provides the use of a patch as specified above for locally reflecting the thermal radiation emitted by the human body and enhancing penetration of an active substance into the skin by a thermal effect.


REFERENCES:
patent: 3520403 (1970-07-01), Moshel
patent: 4619253 (1986-10-01), Anhauser et al.
patent: 353972 (1990-02-01), None
patent: 651984 (1995-05-01), None
patent: 2-145854 (1990-06-01), None
patent: WO 86/00536 (1986-01-01), None

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