Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1998-12-22
2000-05-16
Lankford, Jr., Leon B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 552, 424488, 424499, 435 84, 514 55, C08B 3708, C12P 1926, A61K 3173
Patent
active
060639113
ABSTRACT:
The present invention relates to methods and compositions comprising at least one endothelin antagonist, preferably in combination with a poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide matrix, for use in the treatment of cancer and other proliferative diseases. The endothelin antagonist can be a peptide or non-peptide compound, and the p-GlcNAc matrix of the invention is comprised of a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. The compositions and methods of the invention are useful for inhibiting the growth of tumors and other neoplastic cells and/or for inhibiting the metastasis of neoplastic cells in vivo.
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Finkielsztein Sergio
Pariser Ernest R.
Vournakis John N.
Lankford , Jr. Leon B.
Marine Polymer Technologies Inc.
Tate Christopher R.
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