Selective factor Xa inhibitors

Details Selective factor Xa inhibitors Selective factor Xa inhibitors

1997-10-10

2000-05-16

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514269, 514340, 546193, 5462691, 544319, 544405, C07D41714, A61K 31445

Patent

active

060637943

ABSTRACT:
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

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Edwards, P., et al., "Design, Synthesis, and Kinetic Evaluation of a Unique Class of Elastase Inhibitors, the Peptidyl .alpha.-Ketobenzoxazoles, and the X-ray Crystal Structure of the Covalent Complex between Porcine Pancreatic Elastase and Ac-Ala-Pro-Val-2-Benzoxazol", J. Am. Chem. Soc., 114:1854-1863 (1992).

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