Ipoxygenase inhibitors

Details Ipoxygenase inhibitors Ipoxygenase inhibitors

1983-04-25

1988-07-26

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 20, 560 64, 564163, 564170, 564171, 568731, 568659, C07C 6976

Patent

active

047601612

ABSTRACT:
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit lipoxygenase, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.

REFERENCES:
patent: 3896143 (1975-07-01), Kathawala
Meyer et al. CA81(17)1053732, 1974.
Walsh R. et al., CA88(19):131385u, 1977.
Yamato M. et al., CA87(3):17711b, 1977.
Tashchuk K. et al., CA79(15):91692x, 1973.
Karanewsky, R., CA 104(17)148549x, (1985).
Shidhar, D. R. Indian J. Chem Sect. B 20B(5) 401-3, 1981.
Japanese Patent Specification J57,106,651 as shown in Derwent Farmdoc No. 66912E/32.
D. Bailey et al., Ann Rpts. Med. Chem., 17 203-217 (1982).
R. C. Murphy et al., PNAS USA 76 4275 (1979).
J. L. Humes et al., J. Biol. Chem., 257 1591 (1982).
H. R. Morris et al., Prostaglandins, 19 371 (1980).
M. E. Vol'pin et al., Zh. Obsh. Khim., 29 2855 (1959).
T. Asao et al., Chem. Lett., (1978) 41.

Affiliated with

Also associated with

Rating

Ipoxygenase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ipoxygenase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ipoxygenase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-258740