Piperazino methyl phenyl aminoquinolines

Details Piperazino methyl phenyl aminoquinolines Piperazino methyl phenyl aminoquinolines

1978-05-05

1979-02-20

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544363, A61K 31495, C07D29512

Patent

active

041407750

ABSTRACT:
Antihypertensive compounds of the formula III ##STR1## wherein X is chloro or trifluoromethyl; wherein R is hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R.sub.1 is phenyl or phenyl substituted with one or two alkyl, alkoxy, trifluoromethyl or halo substituents, in which alkyl and alkoxy are each of 1 to 3 carbon atoms, inclusive, and halo is fluoro, chloro or bromo, are prepared by reacting a 4-chloro-7-substituted quinoline of formula I with a compound of the formula II ##STR2## wherein R and R.sub.1 are defined as above. The pharmacologically acceptable acid addition salts of compounds of formula III can also be used as antihypertensive agents.

REFERENCES:
patent: 2474820 (1949-07-01), Burckhalter et al.
patent: 3992382 (1976-11-01), Coverdale et al.
patent: 4025629 (1977-05-01), Coverdale

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