Oximes of oxymorphone, naltrexone and naloxone as potent, select

Details Oximes of oxymorphone, naltrexone and naloxone as potent, select Oximes of oxymorphone, naltrexone and naloxone as potent, select

1985-09-23

1988-07-26

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 45, A61K 31485, C07D48908

Patent

active

047600691

ABSTRACT:
A potent, selective opioid receptor agonist or antagonist exhibiting properties useful for a long-acting analgesic or opiate abuse treatment agent or appetite suppressant having the general formula: ##STR1## wherein R is methyl, cyclopropylmethyl or allyl, and R.sub.1 is an unsubstituted or substituted aryl, aralkyl, heteroaryl, heteroaralkyl or a cycloalkyl group with or without a heteroatom like S,O,N; and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 3135758 (1964-06-01), Fishman
patent: 3153042 (1964-10-01), Fishman
patent: 3320262 (1967-05-01), Lewenstein et al.
Rapoport, et al., J. Organic Chem., vol. 15, pp. 1103-1106 (1950).
Bentley, "The Chemistry of the Morphine Alkaloids", Oxford (1954) pp. 180, 259.
Sawa, et al., Tetrahedron, vol. 24, pp. 6185-6196 (1968).
Hahn, et al., J. Pharm. & Pharmacology, vol. 35(17), pp. 833-836 (12/83).
Ko, et al., J. Med. Chem., vol. 27(12), pp. 1727-1729 (12/84).
Koolpe, et al., J. Med. Chem., vol. 28(7), pp. 949-957 (7/85).
Mohamed, et al., Chemical Abstracts, vol. 104, 8886t (196).

Affiliated with

Also associated with

Rating

Oximes of oxymorphone, naltrexone and naloxone as potent, select does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oximes of oxymorphone, naltrexone and naloxone as potent, select, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oximes of oxymorphone, naltrexone and naloxone as potent, select will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-258103